酮咯酸氨丁三醇眼用凝胶剂对兔金黄色葡萄球菌性角膜溃疡的保护作用  

Protective Effects of Ketorolac Tromethamine Ophthalmic Gel against Staphylococcus aureus Corneal Ulcer in Rabbits

作　　者：胡芳[1] 徐婷君 

机构地区：[1]嘉兴市第二医院眼科,浙江嘉兴314000 [2]平湖市第一人民医院眼科,浙江平湖314200

出　　处：《中国药房》2015年第31期4388-4390,共3页China Pharmacy

摘　　要：目的:研究酮咯酸氨丁三醇眼用凝胶剂对兔金黄色葡萄球菌性角膜溃疡的保护作用。方法:采用角膜实质层接种法复制家兔金黄色葡萄球菌性角膜溃疡模型,随机分为模型组、阳性对照(克拉霉素眼用凝胶)组和凝胶剂高、中、低剂量(酮咯酸氨丁三醇眼用凝胶剂120、80、40 mg/ml)组,每组20只,每日滴药1次,每次1滴。连续给药2周后观察各组家兔角膜病变情况,并对角膜评分和疗效进行比较;显微镜下观察家兔视网膜变化。结果:与模型组比较,阳性对照组和凝胶剂各剂量组家兔给药后角膜评分减小、总有效率增加,且凝胶剂高、中剂量组效果优于阳性对照组,差异有统计学意义(P<0.05)。本实验对家兔视网膜无影响。结论:酮咯酸氨丁三醇眼用凝胶剂对家兔金黄色葡萄球菌性角膜溃疡具有保护作用。OBJECTIVE：To study protective effects of Ketorolac tromethamine ophthalmic gel against Staphylococcus aureus corneal ulcer in rabbits. METHODS：S. aureus corneal ulcer in rabbits model was induced by corneal substance layer inoculation,and then divided into model group,positive control group（Clarithromycin ophthalmic gel）,gel high-dose,medium-dose and low-dose groups（Ketorolac tromethamine ophthalmic gel 120,80,40 mg/ml）,with 20 rabbits in each group. They were given relevant medicine,once a day for 2 weeks. The keratopathy of rabbits was observed;the clinical efficacy and keratopathy score were compared. The change of ratina was observed under micrescope. RESULTS：Compared with model group,the keratopathy score decreased while total effective rate increased in positive control group and gel groups after medication,and the effects of gel high-dose and low-dose groups were significantly lower than that of positive control group,with statistical significance（P〈0.05）.The retina of rabbits had not affected by the experiment. CONCLUSIONS：Ketorolac tromethamine ophthalmic gel has protective effect against S. aureus corneal ulcer in rabbits.

关 键 词：酮咯酸氨丁三醇 眼用凝胶剂 金黄色葡萄球菌 角膜溃疡 家兔 

分 类 号：R965[医药卫生—药理学] R988.1[医药卫生—药学]