(S)-3-{[2'-氰基联苯-4-基]甲基}缬氨酸甲酯盐酸盐合成工艺改进  

Improved Synthesis of(S)-3-{[2'-cyanobiphenyl-4-yl] methyl}Valine Methyl Ester Hydrochloride

作　　者：金灿[1] 臧永军[1] 俞传明[1] 

机构地区：[1]浙江工业大学药学院绿色制药技术与装备教育部重点实验室,浙江杭州310014

出　　处：《浙江化工》2015年第10期15-17,共3页Zhejiang Chemical Industry

摘　　要：报道了以L-缬氨酸甲酯盐酸盐和2'-氰基-4-溴甲基联苯为基本原料经球磨法合成缬沙坦的关键中间体(S)-3-{[2'-氰基联苯-4-基]甲基}缬氨酸甲酯盐酸盐的工艺,收率92%。本工艺反应时间短,收率高,无溶剂,环境友好,具有较好的应用前景。（S）-3-{[2＇-cyanobiphenyl-4-yl] methyl} valine methyl ester hydrochloride was synthesized from L-valine methyl ester hydrochloride and 4-bromomethyl-2-cyanobiphenyl with an overall yield of about92%. The advantages of this method are： shorter reaction time,high yields, solvent free, environmentally friendly and its general applicability.

关 键 词：球磨 缬沙坦 2-氰基-4-溴甲基联苯 L-缬氨酸甲酯盐酸盐 

分 类 号：TQ463[化学工程—制药化工]