中药制剂解毒饮对骨科创伤后炎症反应的影响  

Effect of traditional Chinese medicine Jieduyin on inflammatory response after bone trauma

作　　者：马虎升 冯鹏[2] 赵庆安 史相钦 樊金辉[2] 马潇苒 李东方 孙彦鹏 彭晓东 

机构地区：[1]洛阳正骨医院脊柱外一科,471002 [2]福建中医药大学骨伤学院

出　　处：《中华创伤杂志》2015年第11期1004-1008,共5页Chinese Journal of Trauma

基　　金：河南省中医药科学研究专项基金资助项目（2014ZY02095）

摘　　要：目的探讨中药制剂解毒饮对骨创伤术后炎症反应的影响。方法选择2013年6月-2014年5月收治的100例骨创伤患者，按随机数字表法分为试验组和对照组，每组50例。试验组服用中药解毒饮，对照组服用5g／ml淡红糖水，均连续治疗7d，观察患者术后1d（T1）、3d（T3）、5d（T5）、7a（T7）外周血白细胞（WBC）计数、血清肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）变化、全身炎症反应综合征（SIRS）发病率及SIRS评分变化。结果试验组和对照组T1时WBC计数、TNF-α、IL-6均明显升高，但差异均元统计学意义（P〉0．05）；两组T3、T5、T7时以上指标均有所下降，但试验组较对照组下降幅度大（P〈0．05）。T1时SIRS发生率试验组（74％）和对照组（66％）差异无统计学意义（P〉0．05），T3、T5、T7时差异均有统计学意义（P〈0．05）。SIRS评分T1时试验组（6．2±1．2）分和对照组（6．5±1．3）分差异无统计学意义（P〉0．05），T3、T5、T7时差异均有统计学意义（P〈0．05）。结论解毒饮能抑制炎症的过度反应，降低外周血炎症水平，降低SIRS发生率，对骨创伤后全身炎症反应疗效良好。Objective To evaluate the effect of Jieduyin decoction on inflammatory response after trauma and orthopedic surgery. Methods The study enrolled 100 patients undergone trauma and orthopedic surgery between June 2013 and May 2014. All the subjects were assigned to study group and control group with 50 cases for each according to the random number table. In study group the subject had Jieduyin decoction, but 5 g/ml sugar water in control group for 7 consecutive days. Parameters measured after operation included white blood cell （WBC） count, serum tumor necrosis factor-α （TNF-α）, interlukin-6 （IL-6）, incidence of systemic inflammatory response syndrome （SIRS） and SIRS score. Results Notable increases in WBC count, TNF-α as well as IL-6 were seen in both groups at postoperative 1 day, but the differences between the two groups were all insignificant （P 〉 0.05 ）. These parameters presented some decreases at postoperative 3, 5 and 7 days, greater in study group than in control group （ P 〈 0.05 ）. SIRS incidence and score did not differ significantly between the two groups at postoperative 1 day （P 〉 0.05）, but there were significant differences at postoperative 3, 5 and 7 days （ P 〈 0.05 ）. Conclusion Jieduyin can ameliorate the excessive inflammatory response, reduce inflammatory levels of the peripheral blood, and decrease the incidence of SIRS, which indicates a good therapy for the systemic inflammatory response following trauma and orthopedic surgery.

关 键 词：炎症 创伤和损伤 中草药 

分 类 号：R687[医药卫生—骨科学]