喜炎平注射液辅助治疗支气管哮喘及对患者血浆内皮素、一氧化氮及肿瘤坏死因子-α的影响  

Xiyanping Injection in Adjuvant Treatment of Bronchial Asthma and Its Intervention on Plasma Endothelin,Nitric Oxide and Tumor Necrosis Factor- α

作　　者：袁琛[1] 徐珏[1] 

机构地区：[1]湖州市第一人民医院(湖州市师范学院附属第一医院)儿科,浙江湖州313000

出　　处：《中华中医药学刊》2015年第11期2752-2754,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖州市科技计划项目(2009YSB15)

摘　　要：目的:探讨喜炎平注射液辅助治疗支气管哮喘及对患者血浆内皮素-1(ET-1)、一氧化氮(NO)的影响。方法:180例支气管哮喘患儿,随机分成观察组和对照组。对照组给予常规治疗。观察组在对照组常规治疗方式的基础上,给予喜炎平注射液。结果:治疗后,观察组总有效率91.11%优于对照组75.56%,差异具有显著性(P<0.05)。治疗后,观察组中医证候评分(7.5±2.1)分、哮喘控制测试评分(18.5±4.2)分低于对照组中医证候评分(10.7±2.8)分)、哮喘控制测试评分(16.7±4.5)分,差异有统计学意义(P<0.01)。治疗后,观察组吸入支气管扩张剂次数(2.4±1.1)次低于对照组吸入支气管扩张剂次数(3.1±0.8)次,差异有统计学意义(P<0.01)。治疗后,观察组患者PEF50指标高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组血浆ET-1和NO均低于治疗前,差异具有显著性(P<0.05)。治疗1月后,观察组支气管哮喘患儿血浆ET-1和NO水平(109.5±33.1)pg/m L、(99.5±31.2)μmol/L低于对照组支气管哮喘患儿血浆ET-1和NO水平(135.7±41.8)pg/m L、(119.7±32.5)μmol/L,差异均有统计学意义(P<0.05)。结论:喜炎平注射液辅助治疗支气管哮喘患儿疗效显著,可明显改善患者的血浆ET-1、NO水平。Objective： To study the effects of Xiyanping Injection intervention on plasma endothelin- 1（ ET- 1）,nitric oxide（ NO） levels in children with bronchial asthma. Method： 180 cases of bronchial asthma in children were randomly divided into observation group and control group. The control group： routine treatment. The observation group： based on the routine treatment of the control group,Xiyanping Injection. Results： After treatment,the total effective rate in the observation group 91. 11% was better than 75. 56% in the control group and the difference was significant（ P 〈0. 05）. After treatment,TCM syndrome score（ 7. 5 ± 2. 1）,asthma control test score（ 18. 5 ± 4. 2） of the observation group were higher than the control group＇s TCM syndrome score（ 10. 7 ± 2. 8）,asthma control test score（ 16. 7 ± 4. 5）. The differences were statistically significant（ P 〈0. 01）. After treatment,the number of inhalation of the observation group（ 2. 4 ± 1. 1） was lower than the control group＇s（ 3. 1 ± 0. 8） and the difference was statistically significant（ P 〈0. 01）. After treatment,the PEF50 index of patients of the observation group was higher than that of the control group and the difference was statistically significant（ P〈 0. 05）. After treatment,plasma ET- 1 and NO of two groups were lower than those before treatment and the difference was significant（ P〈 0. 05）. After treatment,plasma of asthmatic children ET- 1 and NO levels in the observation group（ 109. 5 ± 33. 1） pg / m L and（ 99. 5 ± 31. 2） μmol / L lower than the control group＇s（ 135. 7 ±41. 8） pg / m L,（ 119. 7 ± 32. 5） μmol / L and the differences were statistically significant（ P〈 0. 05）. Conclusion： Xiyanping Injection in adjuvant treatment of bronchial asthma in children has good curative effect and can significantly improve the levels of plasma ET- 1 and NO.

关 键 词：喜炎平注射液 支气管哮喘 中医证候 肺功能 内皮素 一氧化氮 

分 类 号：R562.25[医药卫生—呼吸系统]