老年肺结核的治疗效果及影响因素探讨  

Therapeutic Effect and Influence Factors of Senile Pulmonary Tuberculosis

作　　者：汤玉冰[1] 林志鹏[2] 高乾峰[1] 侯浩彬[1] 张振华[3] 

机构地区：[1]安徽医科大学附属六安医院感染科,安徽六安237005 [2]福建医科大学附属泉州第一医院感染科,福建泉州362000 [3]安徽医科大学第一附属医院感染科,安徽合肥230022

出　　处：《现代生物医学进展》2015年第28期5527-5530,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30872160)

摘　　要：目的:探讨老年肺结核的治疗效果及影响因素。方法:选择2012年1月-2014年12月我院就诊的120例老年肺结核患者作为研究对象,记录全部患者的临床资料及基本情况,并对可能影响老年肺结核治疗效果的进行单因素分析及多因素Logistic回归分析。结果:1本研究中120例患者中,其中成功治愈90例,成功治愈率为75%;2单因素分析得出:患者的性别、结核接触史及初复诊情况对老年肺结核治疗效果无显著影响,比较差异均无统计学意义(P>0.05);患者的文化程度、家庭住址、临床症状、有无合并症、痰菌情况、2个月末痰菌检查结果及有无规律服药对老年肺结核治疗效果有显著影响,比较差异均有统计学意义(P<0.05);3经过单因素分析,将有显著差异性的影响因素筛选出来进行多因素Logistic回归分析,结果显示:其中2个月末痰检结果阴性提高肺结核治愈率的影响因素,而有合并症、耐药、文化程度低及临床症状≥3种则是降低老年肺结核治愈率的影响因素。结论:有无合并症、是否耐药、文化程度高低及临床症状情况与老年肺结核的预后密切相关,有规律的服药、积极进行治疗有助于提高老年肺结核患者的成功治愈率。Objective： To investigate the therapeutic effect and influencing factors of pulmonary tuberculosis in the elderly.Methods： 120 cases of senile pulmonary tuberculosis were selected from January 2012 to December 2014 in our hospital as the object of study, the clinical data and the basic situation of all patients were recorded, and the possible influence factors of curative effect for senile pulmonary tuberculosis was made by the Logistic single factor analysis and multi factor regression analysis. Results：1 90 of 120 cases of patients were successfully cured, the cure rate was 75 %; 2The single factor analysis showed the patient＇s sex, contact history and first visit cases had no significant effect on the treatment of senile pulmonary tuberculosis with no statistically significant difference（P〉0.05）;the educational level, family address, clinical symptoms, complications, sputum, sputum examination results after 2 months and regular medication had significant effect on the treatment of senile pulmonary tuberculosis, with significant differences（P〈0.05）; 3 After the single factor analysis, the influence factors with significant difference making a multivariate Logistic regression analysis, the results showed negative sputum smear after 2 months could improve the cure rate of pulmonary tuberculosis and comorbidity, while the complications, resistance to the drugs, low cultural level and clinical symptoms≥3 were the influence factors to the cure rate of elderly pulmonary tuberculosis. Conclusions： Complications, drug resistance, educational level and clinical symptoms are closely related with the prognosis of senile pulmonary tuberculosis. Regular medication and active treatment are helpful to improve the cure rate of elderly patients with pulmonary tuberculosis.

关 键 词：肺结核 老年 治疗效果 影响因素 

分 类 号：R521[医药卫生—内科学]