丹皮酚结肠靶向片的大鼠结肠靶向性评价  

Study on Evaluation of Paeonol Tablets for Colon-specific Delivery in Rats

作　　者：徐本亮[1] 宗时宇 王冰[1] 张彤[1] 陶建生[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《数理医药学杂志》2015年第11期1601-1603,共3页Journal of Mathematical Medicine

基　　金：上海市卫生局项目(20124074);国家自然科学基金(81303233);上海市教委知识服务平台项目;上海中医药大学预算内项目(2014YSN28)资助

摘　　要：目的:研究丹皮酚结肠靶向片剂在大鼠体内定位释药性能。方法:特制适合大鼠口服给药的3mm结肠定位包衣小片,通过相似性因子2评价包衣小片和包衣大片释放曲线的相似性,以小片代替大片进行体内释放评价,考察结肠靶向包衣片剂在大鼠胃、肠道中的释放性能。结果:特制包衣小片的隔离层、时滞层、肠溶层分别增重1.6%、7.3%、9.7%时,释放曲线与包衣大片大致相同,2为53,丹皮酚结肠靶向片75%的药物释放在小肠后端、盲肠以及结肠段,胃及小肠前、中段仅有少量释放。结论:丹皮酚结肠靶向片剂基本达到了结肠定位释药的效果。Objective:To investigate evaluate the absorption property of paeonol colon-specific tablets in vivo.Methods:Using the prescription and technology of big tablet to prepare 3 mm Colon-specific tablet and using it for the experiment in vivo evaluation.In completely perfused rat gastric model was used to investi-gate the releasing property of paeonol colon-specific tablets in vivo.Results:1 .6% weight increase of the iso-lated layer,7.3% weight increase of the sustained-release layer and 9.7% weight increase of the enteric lay-er,the release curve of the special coating tablets was similar to the big tablets and the?2 was 53.75% of the quantities distributed in enteric backend,cecal,colonic tissue and detected a little in gastric and middle of en-teric tissue,but not detected in front of enteric tissue.Conclusion:Paeonol colon-specific tablets have rough-ly reached the effect of the colon-specific drug release.

关 键 词：丹皮酚 结肠靶向片剂 体外释放性能 体内评价 

分 类 号：R283[医药卫生—中药学]