肥胖测量指标与胰高血糖素的相关性研究  

CORRELATION BETWEEN OBESITY INDEX AND SERUM GLUCAGON

作　　者：姜美君[1] 宋俊红[1] 陈洋[1] 姜国辉[2] 张磊[2] 董砚虎[2] 

机构地区：[1]潍坊医学院,内科学专业山东潍坊261042 [2]青岛内分泌糖尿病医院

出　　处：《青岛大学医学院学报》2015年第6期634-637,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨不同肥胖测量指标与血清胰高血糖素的相关性。方法选取68例2型糖尿病及67例非糖尿病病人,均进行标准馒头餐试验或口服75g葡萄糖耐量试验（OGTT）,检测两组病人0、0.5、1.0、2.0h血清中的胰高血糖素水平,分析体质量指数（BMI）、腰围（WC）、腰臀比（WHR）和腰身比（WHtR）等肥胖测量指标与胰高血糖素的相关性。结果 0、0.5、1.0、2.0h时,糖尿病体质量超标准（超标）与肥胖组胰高血糖素水平显著高于糖尿病正常体质量组（H=9.83～16.17,P〈0.05）;0、0.5、1.0h时,糖尿病超标组胰高血糖素水平显著高于非糖尿病超标组（U=174.00～295.00,P〈0.05）;0、0.5、1.0、2.0h时,糖尿病腹型肥胖组的胰高血糖素水平显著高于非糖尿病腹型肥胖组（U=574.00～1 051.50,P〈0.05）,亦显著高于糖尿病正常组（U=51.00～196.00,P〈0.05）。0、0.5、1.0、2.0h时,糖尿病WHtR≥0.52组胰高血糖素水平显著高于非糖尿病WHtR≥0.52组（U=542.00～907.00,P〈0.05）,亦显著高于糖尿病WHtR〈0.52组（U=87.00～159.00,P〈0.05）。糖尿病组胰高血糖素水平与WC、BMI、WHR、WHtR均呈显著正相关（r=0.251～0.418,P〈0.05）。结论肥胖2型糖尿病病人存在高胰高血糖素血症。肥胖非糖尿病病人空腹时亦存在高胰高血糖素血症。控制体质量,尤其是控制腹型肥胖可能有助于肥胖者改善胰腺α细胞功能。Objective To investigate the correlation between obesity index and serum glucagon. Methods Sixty-eight patients with type 2diabetes and 67 patients with non-diabetes were enrolled and received either standardized steamed bread meal test or oral 75 g glucose tolerance test（OGTT）.The serum levels of glucangon at fasting,and 0.5,1.0and 2.0hafter OGTT were measured.The correlation between glucangon level and BMI,WC,WHR and WHtR was analyzed. Results The results of glucagon levels- at 0h,0.5h,1.0h,and 2.0h-were as follows：In overweight or obese diabetic group,the levels of glucagon were higher than that in the diabetics of normal body weight（H=9.83-16.17,P〈0.05）;The levels of glucagon in diabetic overweight group were higher than that in overweight but with no-diabetes group（U=174.00-295.00,P〈0.05）;The levels of glucagon in diabetics of abdominal obesity group were higher than that in non-diabetics of abdominal obesity group（U=574.00-1051.50,P〈0.05）,and also higher than diabetics of normal bodyweight group（U=51.00-196.00,P〈0.05）.When WHtR ≥0.52,the levels of glucagon were higher in diabetic group versus non-diabetics（U=542.00-907.00,P〈0.05）,and also higher than diabetic group of WHtR〈0.52group（U=87.00-159.00,P〈0.05）.In diabetes group,glucagon level was positively correlated with BMI,WC,WHR,and WHtR（r=0.251-0.418,P〈0.05）. Conclusion There is glucagonemia in obese adults with type 2diabetes,and also in obese patients with non-diabetes.Controlling body mass,abdominal obesity in particular,conduces to improving function of pancreatic alpha cells.

关 键 词：肥胖症 胰高血糖素 人体质量指数 腰围 

分 类 号：R587.1[医药卫生—内分泌]