基于“中药溶液环境”学术思想的膜过程研究模式及其优化策略与方法  

The research strategy of membrane process based on the theory of solution environment of water decoction of Chinese medical herbs

作　　者：朱华旭[1,2] 郭立玮[1,2] 李博[1,2] 张宏 杨跃军 刘源才 赵守仁 

机构地区：[1]南京中医药大学江苏省中药资源产业化过程协同创新中心,南京210023 [2]南京中医药大学江苏省植物药深加工工程研究中心,南京210023 [3]江苏久吾高科技股份有限公司无机膜国家地方联合工程研究中心,南京211808 [4]劲牌有限公司,大冶435100 [5]云南白药集团股份有限公司,昆明650118

出　　处：《膜科学与技术》2015年第5期127-133,共7页Membrane Science and Technology

基　　金：国家科技部"十五"科技攻关计划项目(2004BA721A42);国家科技部"十一五"科技支撑计划项目(2006BAI09B07-03);国家自然科学基金项目(30572374;30171161;30873449);国家中医药管理局中医药科学技术研究专项(02-03ZP33);江苏省产学研联合创新基金项目(BY2012036);江苏省六大人才高峰项目(2014-YY-014);江苏省高校中药学优势学科二期建设工程资助项目;南京中医药大学校级科技创新团队资助项目

摘　　要：针对目前中药水提液因组成复杂而难以与新型分离技术接轨的问题,提出"中药溶液环境"概念,根据理论推导和大样本中药体系的数据,挖掘、筛选出可客观、准确、全面反映中药水提液分离性质的理化参数及其数据集,建立"中药溶液环境"表征技术系统.通过"理化参数-高分子组成-膜过程特征相关性"研究,解决中药物料难以建立传质模型的难题.针对"中药溶液环境"建立多尺度、多指标的中药膜过程研究模式,形成面向中药物料的"膜过程优化"系列关键共性技术,即中药物料预处理技术、陶瓷膜精制中药的膜污染预报与防治系统、膜富集挥发油流程与集成技术,中药生产"固液分离、纯化(精制)、浓缩"一体化膜工程设计与实施,实现中药制药生产的高效、环保、稳定与智能控制.The research strategy of＂solution environment＂of water decoction of Chinese medical herbs was put up in allusion to the complicated composition and the difficult connection with modern separation technique.The characterized technology system was built according to the physical and chemical parameters which could reflect the nature of the separation on water decoction objectively,accurately and integrally.Furthermore,all the parameters were selected by theoretical deduction and data mining from large samples with Chinese medical herbs.The problems for establishing models of mass transfer were solved by the study on the correlation with ＂physical and chemical parameters-polymers compositioncharacteristics of membrane process＂.A series of key and common technology on membrane process optimization with Chinese medicine material were formed according to the research mode of multi-scale and multi-index with water decoction of Chinese medical herbs.A series of key and common technology were composed of the preconditioning technique,the preventing and forecasting system of ceramic membrane,and the procedure and integration technique to enriching volatile oil.The high efficiency,environment protection,high stability and intelligent control of Chinese medicine pharmaceutical production were realized through engineering design of integrated membrane technique which was described as＂separation with solid and liquid,purification and concentration＂.

关 键 词：中药水提液 溶液环境 膜过程 表征技术系统 一体化膜工程设计 

分 类 号：R28[医药卫生—中药学]