维生素D_3与雄性生殖  

Vitamin D_3 and Male Reproduction

作　　者：何琳琳 兰飞[2] 徐欢 王永吉 

机构地区：[1]陕西理工学院维生素D生理与应用研究所,汉中723000 [2]陕西理工学院生物科学与工程学院,汉中723000

出　　处：《生理科学进展》2015年第5期334-340,共7页Progress in Physiological Sciences

基　　金：陕西省科技厅科技创新团队项目(2012KCT-29)资助课题

摘　　要：维生素D3的经典作用是调节体内钙、磷的代谢平衡和维持骨的健康,有证据显示维生素D3也可调节动物生殖。维生素D代谢酶可合成和降解活性维生素D3及其代谢中间产物,活性维生素D3通过结合至目标组织的维生素D受体(vitamin D receptor,VDR)以发挥其生物学作用。VDR和维生素D代谢酶在雄性生殖系统中表达,表明维生素D3在雄性生殖生物学中起关键作用。本文对维生素D3与雄性生殖的研究进展作一综述,以期为推进维生素D3影响雄性生殖的分子机制和临床治疗男性不育的研究提供理论依据。The classical effects of vitamin D3 are modulating calcium and phosphorus metabolic balance and maintaining bone health in vivo.It has been shown that vitamin D3 could regulate animal reproduc-tion.Vitamin D metabolic enzymes synthesize and degrade active vitamin D3 and its metabolic intermedi-ates,and active vitamin D3 exerts its biological effects through binding to vitamin D receptor （VDR）. VDR and vitamin D metabolic enzymes expressed in male reproductive system,it suggest that vitamin D3 plays a pivotal role in male reproductive biology.In this review,we mainly focus on the progress of vita-min D3 and male reproduction to provide a theoretical basis for pushing forward the molecular mechanisms research of vitamin D3 effects on male reproduction and clinical therapy for male infertility.

关 键 词：维生素D3 雄性生殖 维生素受体(vitamin Dreceptor VDR) 维生素D 代谢酶 

分 类 号：R339[医药卫生—人体生理学]