脑出血患者脑水肿与精氨酸加压素相关性研究  

A research on the relationship between cerebral edema and the plasma arginine vasopressin in patients with hypertensive intracerebral hemorrhage

作　　者：王宏[1] 姬丽娅 汪平[1] 王安生[1] 章薇[3] 姬西团[3] 孙刚锋[3] 郭世文[4] 

机构地区：[1]西安市中心医院神经外科,陕西西安710003 [2]西安市中心医院神经内科,陕西西安710003 [3]第四军医大学西京医院神经外科,陕西西安710032 [4]西安交通大学第一附属医院神经外科,陕西西安710006

出　　处：《中华神经外科疾病研究杂志》2015年第5期434-436,共3页Chinese Journal of Neurosurgical Disease Research

基　　金：国家自然科学基金资助项目(81172095)

摘　　要：目的探讨高血压脑出血患者血浆精氨酸加压素（AVP）水平与继发性脑水肿的相关性。方法以高血压脑出血患者为研究对象，定时定量采血，采用放射免疫法测量血中AVP浓度，定时复查头颅cT，测量水肿范围，并观察意识状态。结果脑出血后脑水肿1—2h即可出现，并呈进行性加重，1—3d达高峰，持续约2W，早期血浆AVP含量与脑水肿的严重程度及脑水肿持续时间均呈正相关。结论血浆AVP含量与脑出血继发性脑水肿的发生发展存在着密切联系。Objective The relationship between the level of plasma arginine-vasopressin （AVP） and secondary cerebral ederrka is discussed. Methods Blood samples of patients with hypertensive intracerebral hemorrhage were obtained for the measttrement of AVP by radioimmtmoassay method. The patients＇cerebral edema was measured with skull CT scan and the consciousness was monitored. Results The cerebral edema was happened within 1 or 2 h following the intracerebral hemorrhage, and was aggravated continually . The edema peaked at 1 to 3 d and lasted for 2 w. The AVP level in plasma positively correlated with the severity and duration of edema. Condusion There is a close relationship between the plasma AVP level and the incidence and development of secondary cerebral edema in patients with intracerebral hemorrhage.

关 键 词：高血压脑出血 外科学 血管加压素 脑水肿 

分 类 号：R651.1[医药卫生—外科学]