中西医结合治疗老年冠状动脉综合征临床研究  

The Clinical Research into Senile Coronary Syndrome Treated with Combined Therapy of Chinese and Western Medicine

作　　者：乔海峰 

机构地区：[1]朝阳市中心医院,辽宁朝阳122000

出　　处：《河南中医》2015年第10期2369-2371,共3页Henan Traditional Chinese Medicine

基　　金：辽宁省自然科学基金项目(编号:20102149)

摘　　要：目的:观察中西医结合治疗老年急性冠状动脉综合征(ACS)的临床疗效。方法:将280例患者随机分为观察组及对照组,每组各140例。对照组给予阿司匹林联合硝酸异山梨酯,观察组在对照组的基础上加用麝香保心丸。比较两组患者治疗前后血脂、肝肾功能、心肌标志物变化,并观察其治疗期间不良反应情况。结果:两组患者治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著降低,高密度脂蛋白胆固醇(HDL-C)水平均显著升高,观察组变化更为明显,组间比较有统计学差异(P<0.05)。两组患者治疗前后谷草转氨酶(ALT)、谷丙转氨酶(AST)、尿素氮(BUN)、血肌酐(SCr)水平均未见明显变化,组间比较未见统计学差异(P>0.05)。两组患者治疗后C反应蛋白(CRP)、肌酸激酶同工酶(CK-MB)、肌钙蛋白(c Tn I)水平均显著降低,观察组降低更为明显(P<0.05)。观察组有效率为87.1%,对照组有效率为68.6%,两组有效率比较,有统计学差异(P<0.05)。结论:中西医结合疗法能够有效调节老年ACS患者血脂水平,修复心肌损伤,对改善患者的预后具有确切的疗效。Objective： To observe the clinical curative effect of combined therapy of Chinese and Western medicine on senile acute coronary syndrome（ ACS）. Methods： Two hundred and eighty patients were randomly divided into the observation group and the control group,with 140 cases in each group. The ones in the control group were treated with aspirin in combination with isosorbide dinitrate,while the ones in the observation group were added Pill of Moschus for Protecting Heart（ PMPH）. Then the changes of blood fat,kidney and liver functions,myocardial marker of the two groups before and after the treatment were compared; The adverse reactions during the treatment were observed. Results： After the treatment,TC,TG and LDL-C level of the two groups were all obviously reduced,and their HDL-C levels were all obviously improved; And the changes of the observation group were more obvious; And the differences between the two groups were statistically significant（ P〈0. 05）. ALT,AST,BUN and SCr of the two groups before and after the treatment had no obvious changes; And the differences between the two groups had no statistical significance（ P〈0. 05）. CRP,CK-MB,and c Tn I level of the two groups after the treatment were all reduced,and the reduced degree of the observation group were more obvious（ P〈0. 05）. The effective rate of the observation group was 87. 1%,while that of the control group was 68. 6%; And the difference between the two groups were statistically significant（ P〈0. 05）. Conclusion： Combined therapy of Chinese and Western medicine can effectively regulate the blood fat level of senile patients with ACS,repair myocardial injury,and has the exact effect to improve the patient＇s prognosis.

关 键 词：冠状动脉综合征 麝香保心丸 阿司匹林 硝酸异山梨酯 中西医结合疗法 

分 类 号：R259.433[医药卫生—中西医结合]