冠心病患者血浆血管性vWF-CP和GDF15水平的变化及临床意义  

The changes and clinical significance of plasma vascular vWF-CP and GDF15 levels in patients with coronary heart disease

作　　者：张英延[1] 高明明[2] 许景景 

机构地区：[1]山东省莱芜市人民医院心内科,271199 [2]山东省莱芜市人民医院特需科,271199 [3]山东省莱芜市人民医院神经内科,271199

出　　处：《河北医药》2015年第20期3061-3063,共3页Hebei Medical Journal

摘　　要：目的探讨冠心病患者血浆血管性血友病因子裂解酶(v WF-CP)、生长分化因子-15(GDF-15)的改变以及临床意义。方法选取2012年2月至2014年7月治疗的冠心病患者104例,其中稳定型心绞痛患者48例(SAP组),急性冠脉综合征患者56例(ACS组),同时选取类心绞痛患者43例为对照组,检测各组患者血浆v WF-CP、GDF15以及生化指标如总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等。结果 SAP组、ACS组和对照组TC、LDL-C、HDL-C、血肌酐(Cr)和天冬氨酸氨基转移酶(AST)等差异无统计学意义(P>0.05);对照组患者血浆v WF-CP为(612.18±24.07)pg/ml,高于SAP组和ACS组,而SAP组血浆v WF-CP为(373.13±24.09)pg/ml,高于ACS组的(276.39±23.18)pg/ml,3组差异有统计学意义(P<0.05);对照组患者血浆GDF15为(1.42±0.37)ng/ml,低于SAP组和ACS组,而SAP组血浆GDF15为(7.93±0.67)ng/ml,低于ACS组(10.02±0.92)ng/ml,3组差异有统计学意义(P<0.05);冠心病患者血浆v WF-CP和GDF15水平呈负相关(r=-0.702,P<0.05)。结论冠心病患者血浆血管性v WF-CP和GDF15存在相关性,且可在临床上用于预测冠心病患者的风险。Objective To investigate the changes and clinical significance of von Willebrand factor cleaving protease （vWF-CP） and growth differentiation factor-15 （GDF15） levels in patients with coronary heart disease （CHD）.Methods One hundred and four patients with CHD who were treated in our hospital from February 2012 to July 2014 were enrolled in the study,including 48 patients with stable angina pectoris （SAP group）, and 56 patients with acute coronary syndrome （ACS group） ,at the same time, the other 43 patients with similar angina pectoris were served as control group.The plasma levels of vWF-CP, GDF15 and biochemical parameters including total cholesterol （ TC） ,low density lipoprotein cholesterol （ LDL-C） , high density lipoprotein cholesterol （ HDL-C ） were detected for the three groups.R seults There were no significant differences in the levels of TC,LDL-C,HDL-C,Cr and AST between SAP group,ACS group and control group （ P 〉0.05）. The plasma vWF-CP in control group was （612.18 ±24.07） pg/ml, which was significantly higher than that of SAP group and ACS group,moreover, plasma vWF-CP in SAP group was （373.13 ±24.09）pg/ml,which was significantly higher than that of ACS group （276.39 ±23.18）pg/ml （ P 〈0.05）.The plasma GDF15 in control group was （1.42 ±0.37）ng/ml, which was significantly lower than that in SAP group or ACS group ,however,plasma GDF15 in SAP group was （7.93 ±0.67） ng/ml,which is significantly lower than that of ACS group （100.2 ±0.92）ng/ml （ P 〈0.05）.The plasma levels of vWF -CP were negatively correlated to those of GDF15 （ r =-0.702, P 〈0.05）.Conclusion There is a correlation between plasma vWF-CP and vascular GDF15 in patients with CHD,which can be used to predict the risk of patients with CHD in clinic.

关 键 词：冠心病 vWF-CP GDF15 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]