C肽与糖化血红蛋白及脂联素水平对妊娠期糖尿病产后随访的价值  

Values of C-peptide,glycated hemoglobin and adiponectin to the follow-up of postpartum gestational diabetes mellitus

作　　者：孙红杰[1] 许可可 雷厉秀[1] 周芸[1] 杨海燕[1] 

机构地区：[1]深圳市罗湖区人民医院妇产科,广东深圳518001

出　　处：《中华实用诊断与治疗杂志》2015年第11期1114-1115,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：深圳市罗湖区软科研课题项目(2012-52)

摘　　要：目的探讨C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)及脂联素对妊娠期糖尿病(gestational diabetes mellitus,GDM)患者产后随访的价值。方法 114例GDM患者为观察组,同期正常妊娠40例产妇为对照组,比较2组产后42d、6个月、12个月脂联素、HbA1c及C肽水平。结果观察组产后42d、6个月、12个月C肽水平[(0.34±0.27)、(0.46±0.21)、(0.58±0.21)nmol/L]高于对照组[(0.30±0.26)、(0.39±0.26)、(0.41±0.27)nmol/L](P<0.05),脂联素水平[(7.68±2.01)、(7.34±1.96)、(7.44±1.91)mg/L]低于对照组[(7.86±2.03)、(7.75±2.05)、(7.84±2.02)mg/L](P<0.05),产后42d HbA1c水平[(6.5±0.4)%]高于对照组[(5.7±0.3)%],产后6、12个月HbA1c[(5.8±0.3)%、(5.4±0.2)%]与对照组[(5.6±0.2)%、(5.5±0.2)%]比较差异均无统计学意义(P>0.05)。结论监测C肽、HbA1c及脂联素水平可作为筛查GDM患者产后糖代谢异常或糖尿病的有效指标。Objective To investigate the values of C-peptide, glycostlated hemoglobin （HbA1c） and adiponectin to the follow-up survey of postpartum gestational diabetes mellitus （GDM）. Methods The levels of C-peptide, HbAlc and adiponectin were detected 42 days, 6 months and 12 months after delivery in 114 patients with GDM （observation group） and 40 normal pregnant women （control group）. Results The levels of C-peptide were higher in observation group （（0.34±0.27）, （0.46±0.21）, （0.58±0.21） nmol/L） than those in control group （（0.30±0.26, （0.39±0.26）, （0.41±0. 27） nmol/L） （P〈0.05）, and the levels of adiponectin were lower in observation group （（7. 68±2. 01）, （7.34±1.96）, （7.44±1.91） rag/L） than those in control group （（7.86±2.03）, （7.75±2.05）, （7.84±2.02） mg/L） 42 days, 6 months and 12 months after delivery （P〈0.05）. The level of HbA1c was higher in observation group （（6.5± 0.4） ±） than that in control group （（5.7 ± 0. 3）%） 42 days after delivery （P〈0.05）, and there were no significant differences in HbA1c levels between observation group （（ 5. 8 ± 0. 3）%, （5. 4 ± 0. 2）%） and control group （（ 5. 6 ± 0.2） %, （5.5±0.2）%） 6 and 12 months after delivery respectively （P〉0.05）. Conclusion The levels of C-peptide, HbA1c and adiponectin might be used as effective indexes to screen abnormal glucose metabolism and diabetes mellitus for the patients with GDM.

关 键 词：妊娠期糖尿病 C肽 脂联素 

分 类 号：R714.256[医药卫生—妇产科学]