光动力治疗病理性瘢痕的进展  

Photodynamic therapy for the treatment of pathological scars

作　　者：崔晓美[1] 朱晶[1] 陈晓栋[1] 

机构地区：[1]南通大学附属医院皮肤科,江苏226001

出　　处：《国际皮肤性病学杂志》2015年第6期367-369,共3页International Journal of Dermatology and Venereology

摘　　要：病理性瘢痕是皮肤受损伤后的异常愈合，以成纤维细胞增殖和胶原蛋白沉积为特征。临床多采用综合疗法治疗瘢痕，取得了一定的疗效。由于某些治疗手段不良反应较大，患者已存在排斥心理。光动力疗法广泛应用于治疗体表的病变，同时其对体内肿瘤的干预疗效也被进行了较多研究。由于光动力疗法低毒性，国内外学者们对其治疗瘢痕的疗效已进行了大量研究。研究表明，光动力疗法能够抑制成纤维细胞的增殖和迁移，诱导凋亡，抑制胞外基质的形成，改善瘢痕外观，对治疗瘢痕有确切疗效。Pathological scars are caused by abnormal healing after skin damage, and are characterized by fibroblast proliferation and collagen deposition. At clinics, comprehensive therapy is usually applied for treating scars, and has exerted some therapeutic effects. However, the severe adverse effects of some therapies have caused treatment refusal by patients. Photodynamic therapy has been widely used to treat superficial lesions, and has also been well studied for therapeutic intervention in visceral tumors. Because of the hypotoxicity of photodynamic therapy, its therapeutic effect on scars has been widely studied by domestic and foreign scholars. These researches have shown that photodynamic therapy can inhibit the proliferation and migration of fibroblasts, induce apoptosis, inhibit the formation of extracellular matrix, improve the appearance of scars, and exert definite therapeutic effects on scars.

关 键 词：瘢痕 病理过程 光化学疗法 光敏感药 成纤维细胞 胶原 

分 类 号：R622[医药卫生—整形外科]