Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity  

作　　者：Kun Wang Chongwei Chi Zhenhua Hu Muhan Liu Hui Hui Wenting Shang Dong Peng Shuang Zhang Jiezuo Ye Haixiao Liu Jie Tian 

机构地区：[1]Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences

出　　处：《Engineering》2015年第3期309-323,共15页工程（英文）

摘　　要：Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging(CLI), and optical imageguided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment—one of the ultimate goals of precision medicine.Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging （CLI）, and optical image- guided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment--one of the ultimate goals of precision medicine.

关 键 词：optical molecular imaging multimodality molecular imaging optical multimodality tomography Cerenkov luminescence imaging intraoperative image-guided surgery 

分 类 号：TQ02-27[化学工程] O438[机械工程—光学工程]