氧化应激与衰老研究进展  

Oxidative stress and aging

作　　者：原慧萍[1] 杨泽[1] 

机构地区：[1]北京医院卫生部北京老年医学研究所,卫生部老年医学重点实验室,100730

出　　处：《中国老年保健医学》2015年第5期14-17,共4页Chinese Journal of Geriatric Care

基　　金：国家自然科学基金(81061120527;81370445;81472408;81400790);北京市科技新星计划(Z121107002512058);卫生部公益性研究基金(201302008);国家科技部十二五支撑计划项目(2012BAI10B01)

摘　　要：衰老是一个机制颇为复杂的多环节生物学过程,涉及机体多个系统结构与功能的改变。氧化应激学说认为衰老早期阶段,低剂量的活性氧能够激发机体保护性的压力应激反应,延缓衰老;当年龄增加,衰老相关的氧化损伤在体内持续聚集,超过了机体的清除能力,这些蓄积的活性氧加剧衰老相关性DNA损伤,加速细胞的衰老。如何在细胞内部将ROS维持在一个适当的生理水平,而不是单纯地降低细胞内ROS,对于疾病预防、延缓衰老具有重要的研究意义。Aging is a biological process with very complex mechanism which involving the structure and function changes of the various system. The oxidative stress theory claims that low dose of reactive oxygen species can stimulate the body protective response and delay the aging process in the early stage of senescence; when the aging-related oxidative damage was cumulated too huge to be eliminated with age,these ROS will exacerbate aging-related oxidative damage and accelerate the aging process. Instead of reducing cellular ROS merely,maintaining the ROS within an appropriate physiological level will be more important in disease prevention and aging delay.

关 键 词：氧化应激 衰老 自由基 活性氧 

分 类 号：R339.38[医药卫生—人体生理学]