端粒-端粒酶与衰老退行性变的关系  

The relationship between telomere-telomerase and aging development

作　　者：韩晶[1,2] 杨泽[1,2] 

机构地区：[1]北京医院卫生部北京老年医学研究所,卫生部老年医学重点实验室,100730 [2]北京协和医学院研究生院,100730

出　　处：《中国老年保健医学》2015年第5期21-24,共4页Chinese Journal of Geriatric Care

基　　金：国家自然科学基金项目(81061120527;81370445;81472408);国家自然科学基金项目(81370445;81241082)资助;卫生部公益性研究基金(201302008);国家科技部十二五支撑计划(2012BAI10B01);卫计委卫生行业科研专项(201302008);科技部十二五项目(2012BAI10B01)

摘　　要：衰老是一种多因素复合调控的过程,表现为DNA损伤、DNA的甲基化、染色体端粒长度的改变以及细胞的氧化损伤等。近几年的研究也形成了许多有关衰老机制的学说,其中端粒学说成为衰老研究的热点之一。我们已知细胞衰老是器官衰老和机体衰老的基础,而细胞衰老是由于细胞在不断分裂的过程中,端粒长度逐渐缩短、结构功能发生改变所引起的。现对端粒-端粒酶的结构功能及其与衰老关系的研究进展进行综述,并阐明端粒-端粒酶在抗衰老方面有着十分重要的理论价值及实际意义,为攻克医学领域中癌症、衰老和特定遗传病提供新的治疗靶点及治疗方案。Aging is a complex control process of multiple factors,involving alterations of DNA damage,DNA methylation,the change of telomere＇s length and cellular oxidation. In recent years,a lot of theories have been proposed to explain the aging process,and the telomere hypothesis of cellular senescence is becoming one of hot spots. We has known cellular aging is the basis of the organ aging or the boby aging,however,cellular senescence is caused by the gradual shortening of telomere length and the change of it＇s structure in the process of cell division. The structures and functions of telomere-telomerase or the research progress of the relationship between telomerase and aging are reviewed,which will manifest important theoretic and practical significance in antiaging.

关 键 词：端粒 端粒酶 衰老 

分 类 号：R339.38[医药卫生—人体生理学]