左西孟旦对顽固性心衰的疗效研究  

Curative effect of Levosimendan in refractory heart failure and its effect on ventricular arrhythmia and inflammatory factor

作　　者：孟竹[1] 朱静[1] 庄丽[1] 纪霞[1] 崔国方 

机构地区：[1]山东省青岛市市立医院干部保健三科,266071 [2]山东省青岛市海慈医疗集团心内科,266033

出　　处：《中国老年保健医学》2015年第5期63-65,共3页Chinese Journal of Geriatric Care

摘　　要：目的通过左西孟旦对顽固性心衰患者脑钠肽前体(pro-BNP)、心脏彩超左室射血分数(LVEF)及左室舒张末容积(LVEDV)、室性心律失常、炎症因子的影响,来观察研究左西孟旦治疗顽固性心衰患者的效果及其可能的作用机制。方法筛选出顽固性心衰的患者80人,随机分成两组,分别给予左西孟旦和米力农治疗,治疗前后分别测pro-BNP,LVEF,LVEDV,室性心律失常的次数及高敏C反映蛋白(hs-CRP),肿瘤坏死因子-a(TNF-a)。结果与对照组相比,经左西孟旦治疗后患者的pro-BNP水平、室性心律失常的次数显著下降,两组间LVEDV下降值无明显差距,左西孟旦组LVEF显著升高,同时hs-CRP、TNF-a也显著下降。结论左西孟旦治疗顽固性心衰优于传统正性肌力药物。Objectives This study addressed to measure pro-brain natriuretic peptide（ pro-BNP）,left ventricular ejection fraction（ LVEF）,left ventricular end diastolic volume（ LVEDV） and ventricular arrhythmia and inflammatory factor in patients with refractory heart failure,aims to observe the efficacy and action mechanism of Levosimendan. Methods Selected eighty patients with refractory heart failure,that divided into two groups randomly and received Levosimendan or Milrinone treatment respectively. Recorded the dates of pro-BNP,LVEF,LVEDV,hs-CRP,TNF-a and times of ventricular arrhythmia at pretherapy and post-treatment.Results Compared with control group,the levels of pro-BNP and times of ventricular arrhythmia in Levosimendan group were significantly lower. The decrease of LVEDV in the two groups were no gap. The date of LVEF% was higher than that in the Levosimendan group. The hs-CRP,TNF-a in Levosimendan group were significantly lower. Conclusions Levosimendan is better in treating refractory heart failure than that of traditional positive inotropic drug.

关 键 词：左西孟旦 顽固性心衰 心功能 室性心律失常 炎症因子 

分 类 号：R541.6[医药卫生—心血管疾病]