冠心病患者脂蛋白(a)联合多项生化指标的检测分析  

Detection of Lipoprotein( a) Combined with Other Biochemical Indicators in Patients with Coronary Heart Disease

作　　者：林真[1] 张彩琴[1] 金福顺[1] 滕菁[1] 

机构地区：[1]厦门市中医院检验科,福建厦门361009

出　　处：《标记免疫分析与临床》2015年第10期976-977,981,共3页Labeled Immunoassays and Clinical Medicine

基　　金：国家高技术研究发展计划(863计划)子课题。课题编号:2011AA02A111

摘　　要：目的初步分析脂蛋白(a)与超敏C反应蛋白、同型半胱氨酸等在冠心病中的临床检测情况。方法通过观察73例冠心病患者Lp(a)检测结果,比较其与健康组、高血压病组的差异,同时检测冠心病组内其他项目如hs CRP、Fib、HCY等,了解其与冠脉狭窄程度的关系。结果高血压病组、冠心病组脂蛋白(a)水平明显高于健康组,组间差异有统计学意义;冠心病组内HCY、hs CRP、Fib值与冠状动脉粥样硬化狭窄程度有关。结论脂蛋白(a)在冠心病甚或心血管疾病中有检测的临床价值,但有待于质量检测的标准化以对疾病进行风险评估或预警。Objective To investigate the value of detection of plasma levels of lipoprotein-a [ Lp （a）], homocysteine（ HCY ）and hypersensitive C-reactive protein （hs-CRP）in coronary heart disease （CHD）. Methods The levels of Lp （ a）, hs- CRP, Fibrinogen and HCY in 73 patients with CHD, 72 patients with Hypertensive disease （HTN） and 75 healthy controls were detected. The results were analyzed to investigate the relationship between these serum marker levels and the extent of coronary stenosis. Results The serum Lp （a） levels in patients with CHD and HTN were significantly higher than that of controls（ P 〈 0.05 ）. There was close correlation between the level of hs-CRP, Fibrinogen and HCY with the extent of coronary stenosis. Conclusion The serum Lp（a） has a clinical value in the detection of CHD and cardiovascular disease, but it needs to be standardized in order to evaluate the risk of the disease.

关 键 词：冠心病 高血压病 脂蛋白( a) 超敏 C 反应蛋白 同型半胱氨酸 

分 类 号：R541.4[医药卫生—心血管疾病]