榉树叶黄酮类化学成分的研究  

Chemical Components of Flavonoids from Leaves of Zelkova serrata

作　　者：孙崇鲁[1] 汤小蕾[1] 周静峰[1] 吴浩[1] 

机构地区：[1]浙江医药高等专科学校,浙江宁波315100

出　　处：《中国药学杂志》2015年第20期1803-1805,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究榉树(Zelkova serrata)叶中黄酮类化合物的化学成分。方法榉树叶体积分数70%乙醇回流提取物经过硅胶色谱柱色谱、聚酰胺色谱柱色谱、制备薄层色谱及其他分离手段分离纯化,根据化合物理化性质和波谱数据鉴定结构。结果分离得到8个黄酮类成分,分别鉴定为杨梅素(1),二氢杨梅素(2),槲皮素(3),杨梅苷(4),杨梅素-3-O-β-D-吡喃木糖苷(5),槲皮素-3-O-β-D-吡喃木糖苷(6),槲皮苷(7)和芦丁(8)。结论所获得的8个成分均为首次从榉树叶中分离得到。OBJECTIVE To study flavonoids from the leaves of Zelkova serrata. METHODS The leaves were extracted with 70% ethanol by continuous thermal reflux. The extract was separated and purified by silica gel column chromatography,polyamide column chromatography,preparative TLC and other isolation techniques. Their structures were identified by their physical properties and spectroscopic data. RESULTS Eight flavonoids were isolated and identified as myricetin（ 1）,dihydromyricetin（ 2）,quercetin（ 3）,myricitrin（ 4）,myricetin-3-O-β-D-xyloside（ 5）,quercetin-3-O-β-D-xyloside（ 6）,quercitrin（ 7）,and rutin（ 8）. CONCLUSION All compounds were isolated from Schneider Zelkova leaves for the first time.

关 键 词：榉树叶 黄酮 杨梅素 二氢杨梅素 槲皮素 杨梅苷 

分 类 号：R284.1[医药卫生—中药学]