急性前壁心肌梗塞猪模型左室壁三维运动的相关研究  

The Correlation Research on Three- dimensional Motion of Left Ventricular Wall in Pig Model of Anterior Wall Acute Myocardial Infarction

作　　者：陈剑[1] 王庆慧[1] 尹帆[1] 苏璇[1] 现丽妮[1] 罗庆祎[1] 张瑜[1] 丁云川[1] 

机构地区：[1]昆明医科大学附属延安医院医学影像科,云南昆明650051

出　　处：《昆明医科大学学报》2015年第10期9-12,共4页Journal of Kunming Medical University

基　　金：云南省科技厅-昆明医科大学联合专项基金资助项目(2012FB100);云南省教育厅科学研究基金资助项目(2014CD25Y)

摘　　要：目的应用三维斑点追踪技术(three-dimensional speckle tracking,3DT)研究滇南小耳猪急性前壁心肌梗塞前后室壁节段性运动异常与心肌机械力学状态的变化特点.方法选取滇南小耳猪18只,在进行常规二维超声检查和实时全容积成像三维成像图像采集,之后开胸结扎左冠状动脉前降支(LAD)的中下1/3处,于1 h后再次进行常规二维超声检查和实时全容积成像三维成像图像采集,在获取左心室全容积图像后分析图像,自动计算左心室旋转角度(rotation angle,RA)、各节段室壁运动峰值径向应变(radial strain,RS)等参数,并进行对比分析.结果急性前壁心肌梗塞造模后较造模前LVEF、LVFS减小(P<0.05);心梗造模后比造模前左心室旋转角度(rotation angle,RA)、旋转率(rotation rate,RR)、扭转角度(twist angle,TA)及扭转率(twist rate,TR)减小(P<0.05).结论结扎左冠状动脉前降支(LAD)的中下1/3处后,左心室前间隔中间段、前壁中间段、心尖段RS、AS减低,LVEF、LVFS减小,提示左心室局部收缩功能减低从而降低整个左心室心腔内流体力学效率,使心脏搏出量减少,左心室旋转角度(RA)、旋转率(RR)、扭转角度(TA)及扭转率能成为评价冠心病患者左心室扭转的敏感指标.Objective To study the segmental ventricular wall motion and changes of myocardial mechanical state in Diannan Small- Ear pig with anterior wall acute myocardial infarction by using three dimensional speckle tracking（three- dimensional speckle tracking 3DT）.Methods Two- dimensional and Full volume real- time 3D Echocardiography imaging was performed in 18 Diannan small ear pigs before myocardial infarction to analyze the segmental ventricular wall motion of left ventricle. Then the left anterior descending coronary artery（LAD） was ligated at the the lower 1/3 piont, and one hour later, the same all examinations were performed again.The left ventricle（LV） rotation angle（RA）, rotation rate（RR）, torsion angle（TA） and torsion rate（TR） in the apical full- volume image were measured and compared by using three- dimensional speckle tracking imaging.Results After acute anterior wall myocardial infarction,LVEF and LVFS were decreased（P〈0.05）.The pig＇s left ventricular rotation angle（RA）,rotation rate（RR）,torsion angle（TA） and torsion rate（TR） were lower after anterior wall acute myocardial infarction than those before.The difference was statistically significant（P〈 0.05）.Conclusion After the left anterior descending coronary artery（LAD） is ligated at the lower 1/3 piont,Left ventricular anterior middle segment and apical segment＇s RS,AS will decrease.It suggests that the lower left ventricular regional systolic function may reduce the blood flow velocity.It reduces left ventricular intracardiac hydrodynamic efficiency and reduces cardiac stroke volume.The left ventricle（LV） rotation angle（RA）,rotation rate（RR）,torsion angle（TA） and torsion rate（TR） can be sensitive parameters for evaluation of left ventricular rotation in patients with coronary heart disease.

关 键 词：冠心病 心肌梗塞 左心室 三维斑点追踪 

分 类 号：R541.4[医药卫生—心血管疾病]