丙泊酚水溶性衍生物4-[(2,6-二异丙基)苯基-氧基甲酰基]苯甲酸钠制备  

Preparation of Propofol Water-soluble Derivative 4-[(2, 6-diisopropyl)Phenyl-oxygen Radicals Formyl]Sodium Benzoate

作　　者：石红 张金涛 

机构地区：[1]浙江九旭药业有限公司,浙江金华321016

出　　处：《当代化工》2015年第10期2332-2334,共3页Contemporary Chemical Industry

摘　　要：为了制备丙泊酚水溶性衍生物,以丙泊酚为原料,与对腈基苯甲酰氯在缚酸剂存在的条件下作用成酯,再将腈基水解,最后将水解产物与氢氧化钠成钠盐的到丙泊酚水溶性衍生物,4-[(2,6-二异丙基)苯基-氧基甲酰基]苯甲酸钠。制备出产品收率为46.1%,水溶性好,且原料易得,易于工业化生产。In the presence of acid binding agent, propofol reacted with 4-cyanobenzoyl chloride to prepare the ester,then its hydrolysate reacted with Na OH to obtain propofol water-soluble derivative 4-[（2, 6-diisopropyl）phenyl-oxygen radicals formyl]sodium benzoate. The product yield was 46.1%, water-solubility of the product was good.

关 键 词：丙泊酚 丙泊酚衍生物 水解 腈基水解酶 

分 类 号：TQ028[化学工程]