大花金挖耳中单萜类化学成分的研究  

Monoterpenoids from whole plants of Carpesium macrocephalum

作　　者：张建平[1] 杨勇勋[1] 刘庆鑫[1] 陈利萍[1] 李慧梁[1] 

机构地区：[1]第二军医大学药学院,上海200433

出　　处：《中草药》2015年第20期2985-2988,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81102335)

摘　　要：目的研究大花金挖耳Carpesium macrocephalum全草的化学成分。方法采用硅胶、ODS、Sephadex LH-20等色谱方法进行分离纯化,根据理化性质、波谱数据以及X-射线单晶衍射方法鉴定化合物的结构。结果从大花金挖耳丙酮提取物中分离得到5个百里香酚类单萜,分别鉴定为（Z）-10-异丁酰氧基-9-氯-8,9-二羟基百里香酚（1）、9-异丁酰氧基-7,8-环氧-百里香酚异丁酸酯（2）、8-羟基-9-异丁酰氧基-10（2）-甲基丁酰氧基百里香酚（3）、8,10-二羟基-9-异丁酰氧基百里香酚（4）、10-异丁酰氧基-8,9-二羟基百里香酚（5）。结论化合物1为新化合物,命名为大花金挖耳素;化合物2~5为首次从该属植物中分离得到。Objective To investigate the chemical constituents from the whole plants of Carpesium macrocephalum. Methods Its constituents were isolated and purified by means of silica gel, ODS, and Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of chemical evidences, spectroscopic methods, and X-ray data. Results Five thymol monoterpenoids were isolated from the acetone extract in the whole plants of C. macrocephalum and identified as（Z）-10-isobutyryloxy-9-chloro-8,9-dihydrothymol（1）, 9-isobutyryloxy-7,8-epoxythymol isobutyrate（2）, 8-hydroxy-9-isobutyryloxy-10（2）-methylbutyrylthymol（3）, 8,10-dihydroxy-9-isobutyryloxythymol（4）, and 10-isobutyryloxy-8,9-dihydrothymol（5）, respectively. Conclusion Compound 1 is a new chlorinated thymol monoterpenoid named carpemacrom. Compounds 2—5 are isolated from the plants of Carpesium L. for the first time.

关 键 词：天名精属 大花金挖耳 大花金挖耳素 单萜 (Z)-10-异丁酰氧基-9-氯-8 9-二羟基百里香酚 

分 类 号：R284.1[医药卫生—中药学]