中国西沙豆荚软珊瑚Lobophytum sp.化学成分研究  

Chemical constituents from Xisha soft coral Lobophytum sp.

作　　者：郎俊慧[1] 杨帆[2] 甘建红[1] 林厚文[2] 

机构地区：[1]第二军医大学长征医院药学部,上海200433 [2]上海交通大学医学院附属仁济医院药学部,上海200127

出　　处：《中草药》2015年第20期2999-3003,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81072573;81172978;41106127;81001394)

摘　　要：目的研究采自中国西沙群岛海域的豆荚软珊瑚Lobophytum sp.的化学成分。方法利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱和高效液相色谱等方法进行分离纯化,并根据理化性质和波谱数据对化合物的结构进行鉴定。结果从豆荚软珊瑚Lobophytum sp.的乙醇提取物中分离得到5个化合物,分别鉴定为11,12-epoxy-sarcophytonin E（1）、胆甾-5,22-二烯-3β-醇（2）、honulactone A（3）、sarcophytonone（4）、3-dehydroxyl-20-acetylpresinularolide B（5）。结论化合物1为新化合物,命名为豆荚软珊瑚萜A;化合物2~4为首次从该属软珊瑚中分离得到。Objective To investigate the chemical constituents in soft coral Lobophytum sp. collected from the Xisha islands of China. Methods Compounds were isolated and purified by column chromatographies on silica gel, reversed-phase silica gel（ODS）, Sephadex LH-20, and high performance liquid chromatography（HPLC）. Their structures were identified on the basis of physicochemical properties and spectroscopic methods. Results Five compounds were isolated and identified as 11,12-epoxysarcophytonin E（1）, cholest-5,22-dien-3β-ol（2）, honulactone A（3）, sarcophytonone（4）, and 3-dehydroxyl-20-acetylpresinularolide B（5）. Conclusion Compound 1 is a new compound named as chiloboterpene A. Compounds 2—4 are obtained from the soft coral Lobophytum sp. for the first time.

关 键 词：豆荚软珊瑚 Lobophytum sp. 豆荚软珊瑚萜A 胆甾-5 22-二烯-3β-醇 honulactone A sarcophytonone 

分 类 号：R284.1[医药卫生—中药学]