2型糖尿病患者尿足细胞标志蛋白的检测意义  

The expression of urine podocalyxin in patients with type 2 diabetes mellitus and its clinical significance

作　　者：史恒川[1] 刘俊恒[1] 朱建一[1] 

机构地区：[1]江苏省老年医院检验科,江苏省南京市210024

出　　处：《实用老年医学》2015年第10期858-860,共3页Practical Geriatrics

摘　　要：目的探讨老年2型糖尿病不同肾病分期患者尿足细胞标志蛋白(PCX)的变化及其临床意义。方法测定136例老年2型糖尿病患者和50例健康体检者(对照组)尿PCX、尿白蛋白(UALB)、血清肌酐(CREA)、尿素(UREA)水平,按UALB水平将2型糖尿病患者分为3组:尿蛋白正常组、微量白蛋白尿组、临床白蛋白尿组,将各组间检测数据进行分析比较。结果尿蛋白正常组、微量白蛋白尿组、临床白蛋白尿组尿PCX水平均明显高于对照组(P<0.01)。各个组间PCX水平两两比较差异均有统计学意义(P<0.01),PCX水平随着蛋白尿程度的增加而升高(r=0.58,P<0.01)。结论检测尿PCX有利于DM患者肾损害的早期诊断和病变程度的评估。Objective To observe the changes and clinical significace of the urinary excretion of podocalyxin（ PCX） in elderly type 2 diabetes mellitus（ T2DM） patients with different diabetic nephropathy（ DN） stages. Methods136 elderly patients with T2 DM and 50 healthy controls（ control groups） were selected. Serum levels of creatinine（ CREA） and urea（ UREA） and urinary PCX,urinary albumin（ UALB） were examined. All T2 DM patients were divided into three subgroups according to urinary albumin（ UALB） ： normal albuminuria group,microalbuminuria group and clinical albuminuria group. The urinary excretion of PCX and relative clinical data were compared between the four groups.Results Compared with the control group,the level of PCX was significantly increased in each elderly T2 DM subgroup（ P 0. 01）. The levels of PCX in different T2 DM subgroups were statistically different（ P 0. 01）. Correlation analysis showed that PCX was positively correlated with proteinuria（ r = 0. 58,P 0. 01）. Conclusions The detection of urinary PCX is helpful in the early diagnosis of renal injury of T2 DM and assessing the degree of renal impairment.

关 键 词：2型糖尿病 肾病 足细胞标志蛋白 白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌]