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机构地区:[1]广东省惠州市第三人民医院,广东惠州516000
出 处:《广东医学院学报》2015年第3期319-322,共4页Journal of Guangdong Medical College
基 金:惠州市科技计划(医疗卫生)项目(No.2011Y102)
摘 要:目的探讨生活方式干预对口服葡萄糖耐量试验(OGTT)餐后1 h高血糖(OGTT1h HG)的影响。方法将300例OGTT1h HG受试者随机分为观察组和对照组,每组150例。对照组给予一般健康教育,观察组给予生活方式干预,观察1年。在干预6、12个月的时间点比较两组的OGTT1h PG、身体质量指数(BMI)、糖耐量异常(IGT)、糖尿病(DM)的发病率、胰岛素分泌指数(HOMA-B)、胰岛素抵抗指数(HOMA-IR)的情况。结果干预6、12个月后,观察组的OGTT1h PG、BMI水平、IGT和HOMA-IR水平均低于对照组(P<0.05或0.01),转为正常糖耐量(NGT)的达标率和HOMA-B均高于对照组(P<0.01);观察组干预12个月后DM发病率低于对照组(P<0.05)。结论生活方式干预可以有效降低OGTT1h PG水平,改善葡萄糖负荷能力,防止潜在糖尿病患者向DM或IGT转化。Objective To discuss the effects of lifestyle intervention on the oral glucose tolerance test(OGTT) 1h postprandial hyperglycemia(OGTT1h HG). Methods 300 cases of OGTT1 h HG subjects were randomly divided into observation group(150 cases received lifestyle intervention) and control group(150 cases received general health education). The OGTT1 h PG, body mass index(BMI), impaired glucose tolerance(IGT), diabetes mellitus(DM) incidence, insulin secretion index(HOMA-B), insulin resistance index(HOMA-IR) were compared after 6 and12 months. Results The OGTT1 h PG, body mass index(BMI), impaired glucose tolerance(IGT), insulin resistance index(HOMA-IR) of the observation group after treatment for 6 and12 months were all decreased significantly than control group(P〈0.05 or 0.01), and the diabetes mellitus(DM) incidence of the observation group after treatment 12 months was decreased significantly than control group, while the rate of Converted to normal glucose tolerance(NGT) Status and the insulin secretion index(HOMA-B) of the observation group after treatment for 6 and12 months were all increased significantly than control group(P〈0.05 or 0.01). Conclusion The lifestyle interventions can effectively reduce the level of OGTT1 h PG, improve glucose load capacity and prevent this part of the potential conversion to DM or IGT.
关 键 词:口服葡萄糖耐量试验 OGTT餐后1h高血糖 生活方式干预
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