缺血修饰白蛋白联合其他心肌标志物检测在急性冠脉综合征中的早期诊断价值  

Combined detection of ischemia modified albumin and other myocardial markers in the early diagnosis of acute coronary syndrome

作　　者：陈宇锋[1] 钟静敏[1] 唐香祝[1] 陈聪[1] 邹秀娟[1] 黄金波[1] 

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《广东医学院学报》2015年第4期410-412,共3页Journal of Guangdong Medical College

基　　金：茂名市科技计划项目(No.20130334)

摘　　要：目的了解缺血修饰白蛋白联合其他心肌标志物检测在急性冠脉综合征(ACS)中的早期诊断价值。方法 108例经冠状动脉造影确诊为ACS患者于胸痛发作后3、6、12、24 h检测血清缺血修饰白蛋白(IMA)、肌酸激酶同工酶(CK-MB)和肌钙蛋白I(c Tn I)水平,并作心电图检查(ECG),以48例健康人作为对照,评价胸痛发作后3 h单独或联用这些指标对ACS诊断的敏感性和阴性预测值。结果 ACS组IMA水平随时间延长逐渐降低,而CK-MB、c Tn I水平逐渐升高(P<0.01)。胸痛发作后3 h,联用IMA、CK-MB、c Tn I、ECG检测的敏感性和阴性预测值明显优于单项指标检测(P<0.05)。结论联用IMA、CK-MB、c Tn I、ECG检测对ACS早期诊断具有重要价值。Objective To study the early diagnostic value of combined detection of ischemia modified albumin（IMA） and other myocardiac markers in acute coronary syndrome（ACS）. Methods Serum levels of IMA, creatine kinase isoenzyme MB（CK-MB）, cardiac troponin I（c Tn I） and electrocardiogram（ECG） at 3 h, 6 h, 12 h and 24 h after chest pain were determined in 108 ACS patients diagnosed by coronary arteriongraphy. Forty-eight healthy subjects were chosen as controls. The sensitivity and negative predictive value of these indexes for ACS were evaluated at 3 h after chest pain. Results IMA contents were gradually decreased but CK-MB and c Tn I levels increased with time in ACS group（P〈0.01）. At 3 h after chest pain, the sensitivity and negative predictive value of combined detection of IMA, CK-MB, c Tn I and ECG were higher than those of single index（P〈0.05）. Conclusion Combined detection of IMA, CK-MB, c Tn I and ECG is feasible for the early diagnosis of ACS.

关 键 词：急性冠脉综合征 缺血修饰白蛋白 肌钙蛋白I 

分 类 号：R543.5[医药卫生—心血管疾病]