冠状动脉轻度狭窄患者血清ox-LDL、IL-18、MMP-9水平与颈动脉内中膜厚度的相关性  

Correlation between oxidized low density lipoprotein, IL-18, MMP-9 levels and carotid intima-media thickness in patients with mild stenosis of coronary artery

作　　者：陈恩平 杜丽根 邱健[2] 张园[2] 

机构地区：[1]广东省深圳市龙岗区第二人民医院,广东深圳518112 [2]广州军区广州总医院,广东广州510010

出　　处：《广东医学院学报》2015年第4期436-439,共4页Journal of Guangdong Medical College

基　　金：广东省科技计划项目(No.2012B031800418);深圳市龙岗区科技项目(No.201406083001019)

摘　　要：目的探讨冠状动脉轻度狭窄患者血清氧化低密度脂蛋白(ox-LDL)、白介素-18(IL-18)、基质金属蛋白酶-9(MMP-9)水平与颈动脉内中膜厚度(c IMT)的关系。方法 106例冠状动脉造影患者分为对照组、冠脉轻度狭窄组和冠心病组,ELISA法检测其血清ox-LDL、IL-18和MMP-9水平,超声检测c IMT。结果冠心病组ox-LDL、IL-18、MMP-9水平和c IMT明显高于对照组和轻度狭窄组(P<0.01),而轻度狭窄组ox-LDL、IL-18水平和c IMT明显高于对照组(P<0.01)。轻度狭窄组ox-LDL、IL-18与c IMT呈正相关(r分别为0.428和0.405,P<0.01)。结论联合检测血清ox-LDL、IL-18水平可能预测冠状动脉轻度狭窄病变。Objective To investigate the relationship between oxidized low density lipoprotein（ox-LDL）, IL-18, MMP-9 levels and carotid intima-media thickness（c IMT） in patients with mild stenosis of coronary artery（MSCA）. Methods A total of 106 patients underwent coronary angiography were divided into control, MSCA and coronary heart disease（CHD） groups. Serum ox-LDL, IL-18, MMP-9 levels and c IMT were detected by ELISA and ultrasonography, respectively. Results Compared with control group, ox-LDL and IL-18 levels and c IMT were increased in CHD and MSCA groups（P〈0.01）, while MMP-9 contents were elevated only in CHD group（P〈0.01）. Levels of ox-LDL and IL-18 were correlated with c IMT in MSCA group（r=0.423, P〈0.01; r=0.405, P〈0.01）. Conclusion Combined detection of serum ox-LDL and IL-18 levels might predict the MSCA.

关 键 词：冠状动脉粥样硬化 低密度脂蛋白 白介素-18 颈动脉 

分 类 号：R54[医药卫生—心血管疾病]