2010-2014年我院大肠埃希菌耐药率与抗菌药使用量的相关性分析  

Correlation between Escherichia coli resistance and antimicrobial usage between 2010 and 2014 in our hospital

作　　者：郑小清[1] 周秋仁[1] 黄文权[1] 彭琳[1] 曹堃[1] 黎汉坤[1] 黄云平[1] 

机构地区：[1]广东省湛江中心人民医院,广东湛江524037

出　　处：《广东医学院学报》2015年第4期479-482,共4页Journal of Guangdong Medical College

摘　　要：目的分析大肠埃希菌耐药率与抗菌药使用量之间的相关性。方法收集我院2010年1月∽2014年12月13种抗菌药用药频度（DDDs）及大肠埃希菌药敏试验结果,分析二者之间相关性。结果大肠埃希菌对头孢他啶、头孢噻肟耐药率与头孢噻肟用量呈正相关（r分别是0.913、0.884,P〈0.05）,对阿莫西林/克拉维酸和头孢西丁耐药率与左氧氟沙星用量呈正相关（r分别是0.923、0.944,P〈0.05）,对头孢他啶、头孢噻肟、氨曲南耐药率与哌拉西林/他唑巴坦用量呈负相关（r分别是-0.894、-0.880、-0.879,P〈0.05）。结论大肠埃希菌耐药率与抗菌药DDDs之间存在相关性。Objective To analyze the correlation between Escherichia coli resistance and antimicrobial usage. MethodsDefined daily doses（DDDs） of 13 antimicrobial agents and susceptibility test results of E. coli were collected between January 2010 and December 2014 in our hospital, and their correlation was then analyzed. Results Resistance rates of E. coli to ceftazidime or cefotaxime, and amoxicillin/clavulanic acid or cefoxitin were positively correlated with cefotaxime（r=0.913 or 0.884, P〈0.05）, and levofloxacin usage（r=0.923 or 0.944, P〈0.05）, respectively; while resistance rates to ceftazidime, cefotaxime or aztreonam were negatively correlated with piperacillin/tazobactam（r=-0.894,-0.880, or-0.879, P〈0.05）. Conclusion There is a significant correlation between E. coli resistance and antimicrobial DDDs.

关 键 词：大肠埃希菌 抗菌药 耐药 

分 类 号：R978.1[医药卫生—药品]