阿司匹林联合低分子右旋糖酐治疗梗死前心绞痛的疗效观察  

The effect of a combined medicine of aspirin and low molecular weight dextran in treating pre-infarction angina

作　　者：陈勇 何艇 俞四喜 邓秋萍 毛国章 

机构地区：[1]宁波市北仑区中医院急诊内科,浙江宁波315800

出　　处：《健康研究》2015年第5期525-527,共3页Health Research

摘　　要：目的评价阿司匹林联合低分子右旋糖酐治疗梗死前心绞痛患者的临床疗效,探讨其临床适用性。方法78例梗死前心绞痛患者简单随机分为观察组、对照组各39例,对照组患者采用常规治疗,观察组患者在此基础上采用阿司匹林合并低分子右旋糖酐注射液治疗。观察并记录两组患者的心绞痛发作频率、持续时间、硝酸甘油用量,用药期间的不良反应情况,处理结果和主要供血冠状动脉的血流情况。结果治疗前两组患者的心绞痛发作频率、持续时间和硝酸甘油用量比较,差异均无统计学意义(P>0.05);治疗后均显著改善,且观察组患者改善情况显著优于对照组(P<0.05)。观察组患者的心脏事件总发生率(23.08%)显著低于对照组(χ2=13.35,P<0.05);两组患者治疗前左心室前降支的血流参数之间没有明显差异(P>0.05),治疗后均显著升高,且观察组显著高于对照组(均P<0.05)。两组患者用药期间均未出现明显严重的不良症状。结论阿司匹林联合低分子右旋糖酐治疗急诊梗死前心绞痛效果明显,可降低心律失常、心肌梗死和心力衰竭的发生率。Objective To evaluate the clinical efficacy of a combined medicine of aspirin and low molecular weight dextran in treating pre-infarction angina. Methods 78 cases of pre-infarction angina patients were randomly divided into an experimental group and a control group. The control group was treated with conventional therapy while the experimental group was treated with aspirin combined with low molecular dextran. The angina frequency,duration,adverse reactions,nitroglycerin consumption,coronary blood flow and medication of both groups were observed. Findings Before treatment,the differences in seizure frequency,duration and amount of nitroglycerin between the two groups were not statistically significant（ P〈0. 05）; after treatment,the differences were statistically significant（ P〈0. 05）. Those of the experimental group were better than those of the control group. The differences were statistically significant（ P〈0. 05）. The total heart incidence rate（ 23. 08%） of the experimental group was lower than that of the control group of patients（ 64. 10%）. The difference was statistically significant. The flow parameters of descending branch of the left ventricle between the two groups of patients were not significantly different（ P〈0. 05）. The parameters in both groups were significantly improved after thetreatment. The differences were statistically significant（ P〈0. 05） and the improvement of the experimental group was higher than that of the control group. The difference was statistically significant（ P〉0. 05）. There were no obvious symptoms of severe adverse drug as observed during the process of treatment. Conclusion The effect of aspirin combined with low molecular weight dextran as a medicine in treating pre-infarction angina is desirable. It can significantly reduce arrhythmia,myocardial infarction,and the incidence of mental exhaustion.

关 键 词：阿司匹林 低分子右旋糖酐 梗死前 心绞痛 评价 

分 类 号：R541.4[医药卫生—心血管疾病]