溃结灌肠颗粒制备工艺优选研究  

Optimization of Preparation Process of Kuijie Guanchang Granules

作　　者：蒋庆林[1] 夏崇才[1] 

机构地区：[1]南京市中医院,江苏南京210001

出　　处：《亚太传统医药》2015年第21期20-21,共2页Asia-Pacific Traditional Medicine

基　　金：南京市医学科技发展项目(YKK14149)

摘　　要：目的:优选溃结灌肠颗粒的制备工艺。方法:以成型率、流动性、溶化性为指标,筛选赋形剂、润湿剂品种及配比,优选最佳成型工艺。结果:该颗粒的最佳制备工艺:将白芨煎煮液浓缩干燥,粉碎过80目筛,与珠黄散、糊精、浸膏混合制软材,润湿剂为75%乙醇,乙醇用量比为20%,临界相对湿度(CRH)为65%。结论:优选的溃结灌肠颗粒制备工艺稳定可行,可用于大批量生产。Objective：To optimize preparation technology of Kuijie Guanchang Granules.Methods：The best molding process was optimized by taking the shaping rate,fluidity and dissolubility as the indexes,excipient,the types of wetting agents and proportions were screened.Results：The best preparation technology：BaiJi was decocted,concentrated and dried,then mixed with Zhuhuang Powder,dextrin and extract to make soft material,wetting agent was 75% ethanol,ethanol volume ratio was 20% and CRH was65%.Conclusion：This technology was reasonable,feasible,stable,and it could be suitable for preparation of Kuijie Guanchang Granules.

关 键 词：溃结灌肠颗粒 制备工艺 临界相对湿度 

分 类 号：R284[医药卫生—中药学]