尿电解质肌酐比、总蛋白肌酐比在体检和高血压人群中的临床应用  

Application of Urinary Electrolyte / Creatinine Ratio,Urinary Total Protein / Creatinine Ratio In Healthy People and Hypertensive Patients

作　　者：叶桂云[1] 胡望平[2] 池细弟[1] 张忠源[1] 王凯[1] 张永平[1] 

机构地区：[1]福建医科大学附属南平第一医院,353000 [2]中国人民解放军南京军区福州总医院,350025

出　　处：《医学研究杂志》2015年第10期144-148,共5页Journal of Medical Research

摘　　要：目的 运用尿电解质肌酐比计算膳食盐,评价人群盐摄入量. 探讨尿电解质肌酐比、尿蛋白肌酐比（ urinary pro-tein/creatinine ratio, TPCR）在体检和高血压患者中的应用价值. 方法 检测948例（其中842名〉50岁）健康体检者,616例住院高血压患者的尿钠、尿钾、尿总蛋白和空腹血清脂类项目,计算出尿钠肌酐比,尿钾肌酐比、尿钠钾比（ Na＋/K＋）、TPCR和血清载脂蛋白B/A1（apoB/apoA1）. 结果 948例体检者按年龄段分组比较中,尿TPCR在50~60岁年龄组与〉70岁年龄组差异最明显（P=0.000）;842例〉50岁体检者不同性别间比较,尿盐、尿钾差异均有统计学意义（P=0.000）;高血压组与体检组比较,尿TPCR、尿Na＋/K＋、尿盐差异有统计学意义（ P=0 .000 ）;不同级别高血压的尿盐、Na＋/K＋及TPCR等指标均显著增高（ P=0.000）;616例高血压尿总蛋白与尿Na＋/K＋、尿Na＋具有相关性;图中的尿TPCR浓度随年龄加大逐渐上升,高血压尿TPCR与尿Na＋/K＋均显著高于正常体检者. 结论 通过尿电解质计算膳食盐,能简便有效反映人群盐摄入量的高低. 尿电解质肌酐比、尿TPCR与高血压的升级及年龄增大紧密相关.Objective To investigate the salt intake of people by urine electrolytes /creatinine ratio calculating dietary salt and the application of urine electrolytes/creatinine ratio and urinary total protein/creatinine ratio on healthy people and hypertension .Methods Urinary sodium, urinary potassium, urine total protein and fasting serum lipids were detected in 948 （842 cases 〉50 years old） healthy people and 616 hypertensive Patients , and Urinary Sodium /Creatinine Ratio （ USCR） , urinary potassium creatinine ratio , urinary sodium/potassium （Na＋/K＋）, urinary protein creatinine ratio （TPCR） and apoB/apoA1 were calculated.Results Urine TPCR of 50 to 60 years group showed significant difference compared to 〉70 years group by age grouping in 948 participants （P=0.000）.Urine salt and urine potassium of female showed obvious difference compared to male in 842 cases 〉50 years healthy people （P =0.000）.Urine TPCR, urine Na/K and urine salt were significantly highter in hypertension group than healthy group （P =0.000）.Urine salt, Na＋/K＋and TPCR in different levels of hypertension were significantly difference （P =0.000）.Urine TPCR was positively correlated with urine Na＋/K＋and USCR by linear correlation analysis in 616 hypertensive patients .Along the age escalating , urine TPCR increased gradually in figure, urine TPCR and urine Na ＋/K＋were significantly higher in hypertension than health .Conclusion Urine electrolytes/creati-nine ratio is simple and effective to reflect the salt intake .Urine TPCR is closely related with hypertension upgrading and age escalating .

关 键 词：尿电解质肌酐比 总蛋白肌酐比 钠钾比 高血压 膳食盐 

分 类 号：R446[医药卫生—诊断学]