中医药防治多发性硬化的研究进展  

Review on prevention and treatment of multiple sclerosis by traditional Chinese medicine

作　　者：安辰[1,2] 王蕾[1,2] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]中医络病研究北京市重点实验室,北京100069

出　　处：《转化医学研究（电子版）》2014年第4期21-25,共5页Translational Medicine Research(Electronic Edition)

基　　金：国家自然基金(81273742);北京市自然基金(7132031);北京市教育委员会科技发展计划重点项目(KZ201310025023);北京市属高等学校高层次人才引进与培养计划项目-长城学者(CIT&TCD20140329)等项目的资助

摘　　要：多发性硬化(multiple sclerosis,MS)是一种难治性中枢神经系统脱髓鞘疾病,其复发率及致残率高。目前病因和发病机制不明,目前开发的药物不能控制该疾病的发展进程。本文总结了近十年来中医药治疗MS的临床观察和实验研究,并分析中医药治疗MS的优势、存在的问题和今后的设想,为MS患者提供了一条新的治疗途径。Multiple sclerosis（MS） is a kind of refractory demyelinative disease of the central nervous system which characterized with high incidence of recrudescing and deformity.Nowadays,the etiology and pathogenesis of MS are still unknown and the coune of MS cannot be controlled by drugs.Large number clinical studies found that Chinese medicine or combination with western therapy in treating MS patients showed its advantages.This article aims at summarizing the clinical observation and experimental research of traditional Chinese medicine in prevention and treatment of MS in recent ten years.The results showed that Chinese medicine could improve clinical signs and symptoms,reduce the relapse rate,regulate the immune function,reduce the side effects of hormones.Experimental studies showed that Chinese herbal compound,single herb and its active ingredients could improve the clinical symptoms of EAE animals,reducing its neurological function,reduce the immune and inflammatory damage,and had a significant neuroprotective effect.The mechanism may be related with the regulating immune,suppressing inflammation,reducing the demyelination and axonal damage and promoting its regeneration.

关 键 词：多发性硬化 防治 中医药 

分 类 号：R277.7[医药卫生—中医学]