负载盐酸阿霉素交联透明质酸的缓释性能  

Release of cross-linked hyaluronic acid bearing doxorubicin hydrochloride

作　　者：孙小强[1] 刘扬[1] 陈亮[1] 何浩明 李正义[1] 

机构地区：[1]常州大学石油化工学院,江苏常州213164 [2]常州药物研究所有限公司,江苏常州213164

出　　处：《化工进展》2015年第11期4054-4058,共5页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(21002009);江苏省高校自然科学研究重大项目(12KJA150002;14KJA150002);江苏省青蓝工程项目

摘　　要：以抗癌药物盐酸阿霉素为模型,交联透明质酸为载体,通过溶胀作用吸附药物分子,再冷冻干燥、碾压成形,制备了一系列具有不同载药量和一定缓释效果的载药交联透明质酸膜。通过SEM观测其微结构,利用紫外分光光度法检测其药物体外释放行为,并研究不同释放时间、载药量和透明质酸酶对药物释放行为的影响。结果表明,12h内药物释放较快,随后释放平缓,药物累积释放速度与载药量呈反比;加入透明质酸酶后,由于交联透明质酸的不断降解,药物累积释放速度比无透明质酸酶时快。Using anti-cancer drug doxorubicin hydrochloride and cross-linking hyaluronic acid as a model and a carrier respectively,a series of cross linking hyaluronic acid films bearing different loadings of doxorubicin hydrochloride and sustained-release activities have been prepared by swelling in the sorption of drug molecules,freeze-drying,and crushing. Their microstructures and drug release behaviorsin vitro were investigated by SEM and ultraviolet spectrophotometer,respectively. The effects of different time,drug loadings and hyaluronidase,on drug release behavior were studied,and the results showed that the drug releases fast within 12 h,then gets slow,the drug cumulative release speed is inversely proportional to drug loading,and the drug cumulative release speed in the presence of hyaluronidase is faster than that without hyaluronidase because of the continuously degradation of cross-linked hyaluronic acid.

关 键 词：交联透明质酸 盐酸阿霉素 药物缓释 降解 

分 类 号：R318[医药卫生—生物医学工程]