肠安合剂对腹泻型肠易激综合征大鼠血清中5-羟色胺表达的影响  

Effects of Chang'an Mixsture on serum 5-HT of experimental diarrhea type irritable bowel sydrome rats

作　　者：王微[1] 张北华[1] 王凤云[1] 唐旭东[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中华中医药杂志》2015年第11期3905-3909,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81173209);中央级公益性科研院所基本科研业务费专项资金资助(No.ZZ070801)~~

摘　　要：目的:探讨肠安合剂治疗腹泻型肠易激综合征(IBS-D)的药理机制。方法:通过母子分离+慢性束缚刺激的方法制作接近IBS-D临床表现的大鼠模型,将其分为正常组、模型组、肠安Ⅰ号组、肠安Ⅱ号组、痛泻要方组及得舒特组6个实验组,分别给予相应的干预措施,2周后测定各组大鼠血清中5-HT的含量,借助SPSS 20.0统计软件进行统计分析,评价各组大鼠的治疗效果。结果:肠安Ⅰ号组、肠安Ⅱ号组大鼠血清中的5-HT含量均比模型组大鼠降低,其差异具有统计学意义。结论:肠安合剂治疗IBS-D具有显著疗效,其作用机制可能是通过影响血清中5-HT的表达来实现的,同时也为中医药治疗IBS-D提供了一定的现代科学依据。Objective： To investigate the pharmacological mechanism of Chang＇an Mixture in treatment of diarrhea predominant irritable bowel syndrome（IBS-D）. Methods： The IBS-D rat models which symptoms were similar to the clinical symptoms of IBS-D were established by using methods of mother and child separation and chronic bondage, then the rats were divided into control group, model group, Chang＇an Ⅰ group, Chang＇an Ⅱ group, Tongxie Yaofang Formula group and dicetel group, and the rats in each group received the corresponding intervention measures respectively. The contents of serum 5-HT of rats in each group were tested after 2 weeks, and the curative effect of rats in each group was evaluated by using SPSS 20.0 statistical software. Results： The contents of 5-HT both in Chang＇an Ⅰ and Chang＇an Ⅱ groups were less than that of model group, and the difference between the two groups was statistically significant. Conclusion： The curative effect of Chang＇an Mixture was significant in treating IBS-D, and the mechanism might relate to the expression of serum 5-HT, which provided certain modern science basis for treating IBS-D with traditional Chinese medicine.

关 键 词：肠安合剂 腹泻型肠易激综合征 血清5-HT 

分 类 号：R285.5[医药卫生—中药学]