儿童急性呼吸道感染肺炎支原体及嗜肺军团菌IgM抗体检测结果分析  

Analysis of Mycoplasma pneumoniae and Legionella pneumophila IgM antibody testing results in children with acute respiratory tract infection

作　　者：吴雨露[1] 谢成彬[1] 苏喆[1] 易娟[1] 颜源[1] 朱疏影[1] 倪雪梅[1] 

机构地区：[1]四川省妇幼保健院检验科,成都610045

出　　处：《中华妇幼临床医学杂志（电子版）》2015年第5期613-616,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省卫生和计划生育委员会科研课题(120493;130246)~~

摘　　要：目的分析儿童急性呼吸道感染（ARI）者肺炎支原体（MP）及嗜肺军团菌血清1型（LP1）感染情况及流行病学特点。方法选择2013年1～12月，在四川省妇幼保健院儿科临床诊断为ARI的1167例患儿为研究对象。采用间接免疫荧光法检测其血清MP及LP1 IgM抗体，统计学比较不同季度、年龄及性别的MP、LP1及MP＋LP1混合感染阳性检出率差异。结果1167例ARI患儿中，①MP、LP1及MP＋LP1混合感染的阳性检出率分别为25．0％、7．4％及4．3％。②2013年第二季度MP阳性检出率（36．5％）显著高于第一、三、四季度（21．2％、23．1％、22．6oA），且差异均有统计学意义（X^2=7．57，12．07，13．55；P〈0．01）；而LP1及MP＋LP1混合感染的阳性检出率在不同季度比较，差异均无统计学意义（X^2=6．57，5．88；P〉0．05）。③不同年龄患儿的MP、LP1及MP＋LP1阳性检出率比较，差异均有统计学意义（X^2=199．01，35．18，19．89；P〈0．01），而且随患儿年龄增长，MP、LP1及MP＋LP1阳性检出率逐渐升高。④女性患儿MP阳性检出率显著高于男性（29．0％US22．6％，X^2=5．88，P〈0．05），而不同性别患儿的LP1及MP＋LP1阳性检出率比较，差异则无统计学意义（P〉0．05）。结论ARI患儿有较高MP及LP1阳性检出率，应引起儿科医师高度重视。Objective To investigate Mycoplasma pneumoniae （MP） and Legionella pneumophila serogroup I（LP1） infection and epidemiologic characteristics in children with acute respiratory tract infection （ARI）. Methods A total of 1 167 children who were diagnosed as ARI in Sichuan Provincial Hospital of Women and Children from January to December in 2013 were chosen as study subjects. Indirect immunofluorescence assay was used to detect serum IgM antibody of MP and LP1. The positive detection rates were compared statistically amomg different quarters of 2013,age and gender. Results ①The positive detection rates of MP,LP1 and MP＋LP1 were 25.0% ,7.4% and 4.3% respectively in 1 167 ARI patients. ②The positive detection rate of MP in the second quarter of 2013（36.50%） was higher than that in the first, the third and the fourth quarter of 2013 （21. 2%, 23. 1%, 22.6%）, and the differences were statistically significant（X^2 = 7.57,12.07,13.55 ; P〈0.01 ）. There were no significant differences among LP1 and MP＋ LP1 positive detection rates in different quarters of 2013 （X^2 = 6. 57,5. 88; P〉0. 05）.③There were no significant differences among the positive detection rates of MP, LP1 and MP ＋ LP1 in different age of children with ARI （X^2=199.01,35.18,19.89;P%0.01）, and the positive detection rates of MP, LP1 and MP＋LP1 increased with increasing age of children with ARI. ④The positive detection rate of MP in female children with ARI was higher than that in male, and the difference was statistically significant（29.0% vs 22.6%,X^2=5.88,P〈0.05）; but there were no significant differences of LP 1 and MP＋LP1 positive detection rates in different gender （P 〉0. 05）. Conclusion The children with ARI had high positive detection rates of MP and LPl,and should be paid enough attention by paediatricians.

关 键 词：支原体 肺炎 军团病杆菌 嗜肺 免疫球蛋白M 儿童 

分 类 号：R725.6[医药卫生—儿科]