淮安地区婴幼儿人巨细胞病毒感染回顾性分析  

Retrospective analysis of infants with human cytomegalovirus infection in Huai′an

作　　者：李芬[1] 张振[1] 

机构地区：[1]江苏省淮安市淮阴医院检验科,江苏淮安223300

出　　处：《国际检验医学杂志》2015年第21期3115-3116,共2页International Journal of Laboratory Medicine

摘　　要：目的了解淮安地区人巨细胞病毒(HCMV)感染婴幼儿的临床特征。方法对2013年11月至2015年2月确诊的HCMV感染患儿72例进行回顾性分析,包括荧光定量聚合酶链反应(FQ-PCR)法尿HCMV DNA检测结果,以及合并症及临床指标分布特征。结果 72例患儿尿HCMV DNA检测阳性率为90.3%(65/72);72例患儿中,合并肺炎60例(83.3%),合并肝炎34例(47.2%),合并血液系统损伤14例(19.4%),合并神经系统损伤3例(4.2%),合并两种及其以上并发症28例(38.9%)。结论 FQ-PCR是检测HCMV感染的良好方法。HCMV感染患儿易出现肺炎、肝炎、血液系统损伤等临床表现。采用FQ-PCR对疑似HCMV感染患儿进行HCMV DNA检测有助于疾病的早期诊治。Objective To investigate the infection characteristics of human cytomegalovirus（HCMV）in infants of Huai′an area.Methods Clinical data of 72 infants with HCMV infection,diagnosed from Nov.2013 to Feb.2015,were retrospectively analyzed,including HCMV DNA level of urine samples,detected by using fluorescent quantitative-polymerase chain reaction（FQ-PCR）,and complications and clinical characteristics.Results The positive rate of HCMV DNA was 90.3%（65/72）.Among all of the infected infants,60cases（83.3%）were with pneumonia,34cases（47.2%）were with hepatitis,14cases（19.4%）were with hematological diseases,3cases（4.2%）were with neurological diseases,and 28cases（38.9%）were with two or more than two types of complications.Conclusion FQ-PCR might be useful for the detection of HCMV infection.Clinical manifestation of pneumonia,hepatitis,hematological diseases,and so on might be common in HCMV infected infants.FQ-PCR,used to detect HCMV DNA,could be helpful for the early diagnosis and treatment of HCMV infection.

关 键 词：人巨细胞病毒 荧光定量-聚合酶链反应 诊断 治疗 

分 类 号：R725.1[医药卫生—儿科] R446[医药卫生—临床医学]