加巴喷丁联合小剂量丁丙诺菲透皮贴治疗糖尿病周围神经痛的临床观察  

Clinical observation on combined buprenorphine transdermal patch and gabapentin in the treatment of diabetic peripheral neuralgia

作　　者：何颖[1] 万成福[2] 宋涛[2] 

机构地区：[1] 铁岭市妇婴医院麻醉科,辽宁省铁岭112000 [2] 中国医科大学附属第一医院疼痛科

出　　处：《中国医师杂志》2015年第10期1465-1467,共3页Journal of Chinese Physician

基　　金：基金项目：国家自然科学基金资助项目（81271371）

摘　　要：目的 观察加巴喷丁联合小剂量丁丙诺菲透皮贴治疗糖尿病周围神经痛的临床效果.方法 60例糖尿病周围神经痛患者随机分为两组,对照组单独应用加巴喷丁,观察组加巴喷丁联合应用丁丙诺菲透皮贴.治疗8周后记录两组患者用药前、用药后2、4、8周的疼痛视觉模拟评分（VAS）、睡眠评分、加巴喷丁日剂量及不良反应发生率.结果 两组患者治疗后各时间点VAS评分明显低于治疗前（P＜0.05）;用药治疗后两组患者睡眠质量明显改善（P＜0.01）;观察组加巴喷丁的日剂量明显减少（P＜0.05）;观察组头晕、嗜睡的发生率明显低于对照组（P＜0.05）.结论 加巴喷丁联合小剂量丁丙诺菲透皮贴对糖尿病周围神经痛患者的镇痛效果较好,不良反应较小.Objective To observe the effect of buprenorphine transdermal patch combined with gabapentin in patients with diabetic peripheral neuralgia （DPN）. Methods Sixty patients were divided randomly into experimental （A） and control （B） groups. Patients in group A were treated with buprenor- phine transdermal patch combined gabapentin. Patients in group B were orally administered pregabalin only. The period of treatment was 8 weeks. The analgesic effect [ visual analogue scale （VAS） scores ], sleep scores, daily doses of gabapentin, and adverse reactions were evaluated before treatment, and the 2nd weeks, 4th weeks and 8th weeks after treatment. Results The VAS scores of group A were significantly lower than group B at 4th weeks and 8th weeks after treatment [ （2. 8 ±1.6）points vs （3.8± 1.5 ） points, （2. 6 ± 0. 5 ） points vs （ 3.5± 1.6 ） points, P 〈 0. 05 ]. The sleep scores of group A were significantly higher than group B （ P 〈 0.01 ）. The daily doses of gabapentin were significantly lower [ （ 853.0 ± 349. 8）mg vs （1575.8 ±351.0）mg,（845. 1 ±342. 7）mg vs （1434. 2 ±440. 8）mg,（826. 9 ±298.5）rag vs （1389.8 ±356. 6）mg, P 〈 0. 05 ]. The incidence of adverse reactions was significantly lower in group A （ 10. 7% vs 25.9% , 10. 7% vs 29. 6%, P 〈 0. 05 ）. Conclusions The combination of buprenorphine transdermal patch and gabapentin is effective and safe for the patients with DPN.

关 键 词：γ氨基丁酸/类似物和衍生物/投药和剂量 丁丙诺啡/投药和剂量 糖尿病神经病变/药物疗法 

分 类 号：R587.2[医药卫生—内分泌]