冠状动脉轻度狭窄患者动脉弹性与ox-LDL、IL-6及MMP-3的关系  

Correlation of arterial elasticity with ox-LDL,IL-6 and MMP-3 in patients with mild stenosis of coronary artery

作　　者：杜丽根 邱健[2] 陈恩平 张园[2] 

机构地区：[1]广东省深圳市龙岗区第二人民医院内科,518112 [2]广州军区广州总医院心血管内科,广州510010

出　　处：《广东医学》2015年第20期3141-3143,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2012B031800418);广东省深圳市龙岗区科技发展资金医疗卫生(非扶持类)项目(编号:YLWSF201406083001019)

摘　　要：目的观察动脉弹性、氧化低密度脂蛋白(ox-LDL)、白细胞介素-6(IL-6)、基质金属蛋白酶-3(MMP-3)在冠心病特别是冠状动脉(冠脉)轻度狭窄患者中的变化情况,评价其临床意义。方法将132例患者根据冠脉造影结果分为对照组、冠脉轻度狭窄组、冠心病组,用欧姆龙科林动脉硬化检测仪检测反映动脉弹性的肱-踝脉搏波传导速度(ba PWV),静脉抽血ELISA方法检测ox-LDL、IL-6、MMP-3。结果 3组比较ba PWV、ox-LDL、IL-6、MMP-3差异均有统计学意义(P<0.05)。与对照组比较,冠脉轻度狭窄组ba PWV、IL-6、oxLDL明显升高(P<0.05),MMP-3未见明显升高,差异无统计学意义(P>0.05)。将选入的患者ba PWV与oxLDL、IL-6做直线相关分析,结果呈正相关(r=0.472、0.523,P<0.001)。在控制了吸烟、高血压病史、糖尿病史等多种动脉粥样硬化危险因素后,这种相关性仍然存在(r=0.435、0.506,P<0.01)。结论冠脉轻度狭窄患者动脉弹性与炎症和氧化应激、炎症密切相关,提示动脉弹性、氧化应激与炎症参与了早期冠脉粥样硬化的发生与发展,联合这些指标的检测可能可以预测冠脉的轻度狭窄病变。Objective To investigate the changes of arterial elasticity, levels of ox - LDL, IL - 6 and MMP - 3 and their clinical significance in patients with mild stenosis of coronary artery. Methods One hundred and thirty - two patients who underwent coronary angiography were divided into three groups according to the resuh of CAG ： coronary heart disease group, the group with mild stenosis of coronary artery and control group. Brachial - ankle pulse wave velocity （baPWV） , which reflected arterial elasticity, was measured by a Colin system. Serum levels of ox -LDL, IL -6 and MMP- 3 were measured via ELISA before angiography in all subjects. Results Statistically significant differences were observed among three groups in baPWV and the levels of ox - LDL, IL - 6 and MMP - 3 （ P 〈 0. 05 ）. Comparing with the control group, there were significant increases in baPWV and levels of ox - LDL, IL - 6 in the group with mild stenosis of coronary artery （ P 〈 0. 05 ）. Levels of MMP - 3 were not significantly different between the two groups （ P 〉 0. 05 ）. baP- WV was positively correlated with ox - LDL and IL - 6 （ r = 0. 472,0. 523 ; P 〈 0. 001 ）. The correlation remained after control for risk factors of atheroselerosis such as smoking, hypertension and diabetes （ r = 0. 435, 0. 506 ; P 〈 0. 01 ）. Conclusion Changes of arterial elasticity is correlated with inflammation and oxidative stress in patients with mild stenosis of coronary artery, which indicates their contribution to occurrence and development of early coronary atherosclerosis. Detection of these indicators may predict mild stenosis of coronary arteries.

关 键 词：冠心病 动脉弹性 白细胞介素-6 氧化低密度脂蛋白 基质金属蛋白酶-3 

分 类 号：R816.2[医药卫生—放射医学]