水甘油通道蛋白7、9与肥胖和2型糖尿病发生研究进展  

Research progress in association of AQP7,9 with development of obesity and type 2 diabetes

作　　者：王益君[1] 王春[2] 向全永[1] 

机构地区：[1]南通大学公共卫生学院环境卫生学教研室,江苏南通226019 [2]江苏省疾病预防控制中心慢性非传染性疾病防制所

出　　处：《中国公共卫生》2015年第11期1517-1520,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(21347005);江苏省自然科学基金(BK20131202;YKC13041);江苏省卫生科研项目(H201224);南通大学博士启动项目(13B37)

摘　　要：糖尿病是一种代谢紊乱疾病,其病因不是单一的,而是复合病因综合征,严重影响着人们的生活质量。随着分子生物学技术飞速发展,人们对糖尿病的认识也更加深入,许多学者开始在体液代谢异常上展开研究。水甘油通道蛋白作为介导甘油的通道,参与脂肪合成与分解等一系列重要的代谢过程,因而水甘油通道蛋白及其相关基因的研究,对糖尿病的治疗与控制的意义非常重大。Diabetes mellitus, a kind of metabolic disorder disease caused by multiple factors, has seriously impacted on the quality of life of the sufferers. With rapid development of techniques in molecular biology, the knowledge about di- abetes has been more thorough. Researchers pay more attentions to explore the associations between body fluid metabolic abnormalities and diabetes. Aquaporins （AQPs） which are known as glycerol transporters have been demonstrated to participate in a series of important metabolism processes including fat synthesis and decomposition. Exploring the effects of AQPs and its related genes on the occurrence of diabetes has great importance for the treatment and prevention of diabetes.

关 键 词：水甘油通道蛋白 脂肪代谢 2型糖尿病 胰岛素抵抗 

分 类 号：R181.2[医药卫生—流行病学]