胃肠胰神经内分泌瘤相关微RNA的研究进展  

Research Progress and Clinical Application of miRNAs in Gastroenteropancreatic Neuroendocrine Tumors

作　　者：杨逸[1] 王志刚[1] 

机构地区：[1]上海交通大学附属第六人民医院普外科,上海200233

出　　处：《医学综述》2015年第21期3883-3886,共4页Medical Recapitulate

摘　　要：微RNA（miRNA）是一类具有21~22个核苷酸的非编码小分子RNA,通过在转录后水平调节靶基因的表达,参与细胞的增殖、分化、凋亡等多种生理过程。miRNA具有促癌或抑癌作用,在人类肿瘤的起源与演进过程中起重要作用,充当促癌基因或者抑癌基因作用,是极具敏感性的生物标志物及治疗靶点;相较正常组织,miRNA在胃肠胰神经内分泌瘤中亦存在显著差异表达,具有潜在临床价值。MicroRNAs（miRNAs） are a family of 21-22 nucleotides, non-coding small RNAs that func- tion as posttranscriptional gene regulators. They are involved in critical biologic processes including prolifera- tion, differentiation and apoptosis. A myriad of studies have demonstrated that miRNAs can act as tumor-sup- pressors or oncogenes in the origin and progress of human neoplasms. Aberrant miRNA expression can be a sensitive hallmark and therapeutic target. It is reported that aberrant miRNA expression is also occurred in the development and progress of gastroenteropancreatic neuroendocrine tumors, which is of potential clinical value.

关 键 词：微RNA 神经内分泌瘤 胃肠道 胰腺 

分 类 号：R656[医药卫生—外科学] R735[医药卫生—临床医学]