静脉注射吸毒人群 HIV／HCV 混合感染者与 HIV 单独感染者艾滋病疾病进展比较分析  

Comparative analysis of HIV disease progression between IDUs with HIV/HCV co-infection and those with HIV infection

作　　者：李世福[1] 付金翠[1] 李再友[1] 郭春园[1] 许杰[1] 赵金仙[1] 高良敏[2] 

机构地区：[1]云南省玉溪市疾病预防控制中心,653100 [2]清华大学医学院公共健康中心,北京100008

出　　处：《中华微生物学和免疫学杂志》2015年第9期692-697,共6页Chinese Journal of Microbiology and Immunology

摘　　要：目的：对静脉注射吸毒人群中HIV感染者与HIV／HCV混合感染者的疾病进展及死亡情况进行对比分析，探讨HIV／HCV混合感染对HIV感染者自然病程的影响。方法对2006—2014年间吸毒人群哨点监测报告的HIV单独感染者与HIV／HCV混合感染者进行回顾性研究，获取CD4^＋T淋巴细胞计数数据，通过艾滋病综合防治信息系统获得HIV／AIDS死亡的相关数据，两组人群进行对比分析。结果175例HIV单独感染者首次CD4^＋T淋巴细胞计数平均值为370个／μl，且小于200个／μl的为25．71％，月均CD4^＋T 淋巴细胞计数自然变化速率为：－1．50个／μl，1年内病死率为18．18％，352例HIV／HCV混合感染者首次CD4^＋T 淋巴细胞计数平均值为420个／μl，且小于200个／μl的为20．45％，月均CD4^＋T 淋巴细胞计数自然变化速率为：－2．76个／μl，1年内病死率为32．14％，两组人群差异均有统计学意义（P＜0．05）。结论与HIV单独感染者相比，HIV／HCV混合感染者被发现时免疫状况尚可，但是其CD4^＋T淋巴细胞计数下降速度较快，疾病进展快，死亡速度也较快。必须加快制定针对HIV／HCV混合感染者的防治策略。Objective To comparatively analyze the HIV disease progression and the death situa-tion between injecting drug users （IDUs） with HIV infection and those with HIV/HCV co-infection.Methods The counts of CD4^＋T cells were collected through a retrospective study and the data about death situation were collected with follow-up cards from 2006 to 2014 .A statistical analysis was conducted for the two groups .Results Among the 175 cases with HIV infection , the average value of primary CD4^＋T cell counts was 370 cell/μl and 25.71%of them, primary CD4^＋T cell counts were less than 200 cell/μl.The average change rate of CD4^＋T cell counts was -1.50 cell/μl in month.The annual mortality rate was 18.18%. Among the 325 cases with HIV/HCV co-infection, the average value of primary CD4^＋T cell counts was 420 cell/μl and 20.45%of them, primary CD4^＋T cell counts were less than 200 cell/μl.The average change rate of CD4^＋T cell counts was -2.76 cell/μl in month.The annual mortality rate was 32.14%.The differ-ences between the groups were significant （P〈0.05）.Conclusion Compared with patients with HIV infec-tion, those with HIV/HCV co-infection showed significantly decreased CD4^＋T cell counts , resulting in a faster disease progression and a faster death .It was urgent for the management department to work out HIV prevention and therapeutic measures .

关 键 词：艾滋病 HIV/HCV混合感染 疾病进展 CD4+T淋巴细胞计数 死亡 

分 类 号：R512.91[医药卫生—内科学]