长链非编码RNA与心血管疾病的关系  

Relationship Between Long Non-coding RNA and Cardiovascular Disease

作　　者：钱海霞[1] 季林丹[1] 徐进[1] 

机构地区：[1]宁波大学医学院,宁波315211

出　　处：《中国细胞生物学学报》2015年第10期1441-1446,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81402747);浙江省自然科学基金(批准号:LQ13C060001);浙江省教育厅科研项目(批准号:Y201224146)资助的课题~~

摘　　要：心血管疾病是当今全球人群的首要死因,也是引起期望寿命损失最主要的疾病。大量研究用流行病学、病理生理学、分子生物学等方法揭示该类疾病的发病机制,并取得了重大进展。近年来,随着遗传学和生物信息技术的飞速发展,越来越多的研究发现长链非编码RNA(long noncoding RNA,lnc RNA)与心血管疾病的发生、发展、诊断和治疗密切相关。该文就lnc RNA与心血管疾病的关系作一综述,以期帮助读者了解lnc RNA在心血管疾病发生发展中的作用。Cardiovascular disease is the leading cause of human death in the world, which is also the major cause for loss of life expectancy. A great number of studies have been carried out to delineate the underlying mechanisms through epidemiological, pathophysiological or molecular methods, and have made significant progress. With the rapid development of genetic and bioinformatical technologies, recent studies have found that the long non-coding RNA （lncRNA） is closely associated with the development, prognosis, diagnosis and treatment of cardiovascular disease. This review summarizes the current state of knowledge about the association between IncRNA and cardiovascular disease, which may help the readers understand the important roles of lncRNA in the oatho^enesis of cardiovascular disease.

关 键 词：长链非编码RNA 心血管疾病 表观遗传学 发病机制 

分 类 号：R54[医药卫生—心血管疾病]