低氧诱导因子-1与缺血性心肌损伤保护的研究进展  

Advances in HIF-1 and Cardioprotection of Ischemic Myocardial Injury

作　　者：丁然然[1,2] 哈艳平 王振良[1,2] 雷洪[1,2] 申志华[3] 郭峻莉[4] 揭伟[1,2] 

机构地区：[1]广东医学院病理学系,湛江524023 [2]广东医学院附属医院病理诊断与研究中心,湛江524001 [3]广东医学院病理生理教研室,湛江524023 [4]海南医学院心血管研究所,海口570102

出　　处：《中国细胞生物学学报》2015年第10期1447-1457,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81000073;81160020;81170121;81460042);广东省教育厅科技创新项目(批准号:2013KJCX0088);广东医学院优硕培育基金(批准号YS2014013;YS2015004;YS2015005)资助的课题~~

摘　　要：低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是一个关键和特异的核转录因子,也是联系低氧、缺血损伤等病理现象的纽带。HIF-1通过作用于低氧反应元件在转录水平调控一系列低氧反应基因表达以介导细胞对低氧的应答,在缺血缺氧性疾病中发挥着重要的生物学功能。缺血性心肌病是临床上常见的致死性疾病,HIF-1与缺血性心肌病的病理生理关系密切,在受损心肌的保护反应中发挥重要作用。该文就HIF-1功能调节、在缺血性心肌损伤中的表达调控及参与心肌保护机制的研究进展作一综述,并展望了基于HIF-1靶点进行缺血性心肌病防治的临床意义。Hypoxia-inducible factor-1 （HIF-1） is a critical and specific nuclear transcriptional factor, which associates with the pathological phenomena of hypoxia and ischemic injury. HIF-1 plays an important biological role in hypoxic-ischemic diseases through transcription of a series ofhypoxia response genes archived with hypoxia response element. Ischemic heart disease is a common clinical fatal etiology, and HIF-1 is tightly associated with the pathophysiology of ischemic heart disease, which plays an important role in protecting the injured myocardium. In this paper, the functional mediation, the regulation of HIF-1 expression in ischemic myocardial injury and the progress in myocardial protection mechanisms are reviewed. Besides, we also prospect the significance of clinical effects of prevention targeted at HIF-1 on ischemic heart disease.

关 键 词：低氧诱导因子-1 缺血性心肌病 心肌保护 

分 类 号：R542.2[医药卫生—心血管疾病]