血必净注射液对创伤性凝血病患者血制品输注及炎症因子的影响  

The effect of Xuebijing injection on transfusion and inflammatory factors in patients with traumatic coagulopathy

作　　者：马明远[1] 江皓波[1] 张云海[1] 邓梦华[1] 于娜[1] 戚振红[1] 

机构地区：[1]广东省佛山市中医院重症医学科,528000

出　　处：《实用医学杂志》2015年第20期3415-3418,共4页The Journal of Practical Medicine

基　　金：广东省佛山市医学类科技攻关项目(编号:201208077)

摘　　要：目的:探讨血必净注射液对创伤性凝血病患者的血制品输注及全身炎症状态的影响。方法:共79例患者纳入研究,随机分为治疗组(36例)和对照组(43例)。对照组接受常规治疗,治疗组在此基础上加用血必净注射液。检测两组患者不同时间点的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平,统计其血制品使用情况,并进行比较。结果:治疗前后比较:两组患者凝血功能的异常基本纠正;组间比较:治疗组输注的红细胞、新鲜冰冻血浆、冷沉淀量少于对照组,差异有统计学意义(P<0.05)。收治后72 h,治疗组TNFα、IL-6、IL-8水平低于对照组,差异有统计学意义(P<0.05)。结论:血必净注射液可减少创伤性凝血病患者血制品的使用量,考虑与其拮抗全身炎症反应的作用有关。Objective To study the effect of Xuebijing injection on transfusion and systemic inflammation in traumatic coagulopathy patients. Methods Seventy-nine patients were randomly divided into Xuebijing Group （36 cases） and Control Group （43 cases）. Xuebijing group received Xuebijing injection in addition to the regular treatment received by control group. Levels of TNF-α, IL-6, IL-8 and transfusion amount between two groups were compared. Results Coagulation abnormality was almost corrected in all patients after treatment. In Xuebijing Group, transfusion of RBC, FFP and cryoprecipitate were significantly less than that in control group （P〈0.05）. At 72 h after admission, TNFα, IL-6 and IL-8 were significantly lower in Xuebijing Group （P 〈 0.05）. Conclusion Xuebijing injection could reduce transfusion in traumatic coagulopathy patients , possibly resulting from its antagonism against systemic inflammation.

关 键 词：血必净注射液 创伤性凝血病 血制品输注 炎症反应 

分 类 号：R641[医药卫生—外科学]