泰国葛根化学成分研究  

Study on chemical constituents of Pueraria mirifica

作　　者：刘喜舞 叶惠煊[2] 戴玲 刘向前[2] 

机构地区：[1]武警湖南省总队医院药剂科,长沙410006 [2]湖南中医药大学药学院,长沙410208 [3]长沙博海生物科技有限公司,长沙410205

出　　处：《西北药学杂志》2015年第6期664-666,共3页Northwest Pharmaceutical Journal

基　　金：长沙市科技局科技计划重点项目(编号:K1207010-21)

摘　　要：目的研究泰国葛根的化学成分。方法泰国葛根样品用正己烷提取除杂后,药渣用乙酸乙酯提取,得到的滤液浓缩后,用甲醇提取得到精制乙酸乙酯部位;乙酸乙酯提取后的药渣用甲醇提取,浓缩后再用正丁醇萃取得正丁醇部位;利用正相硅胶、MDS-5等常规柱色谱技术分离得到单体化合物,根据其理化性质及波谱学数据鉴定其化学结构。结果分离得到5个单体化合物,分别被鉴定为Mirificoumestan(1),十七烷酸(2),去氧葛雌素(3),葛根素(4),大豆苷(5)。结论化合物2是首次从该植物中分离得到。Objective To study the chemical constituents of Puerariamirifica .Methods Puerariamirifica was extracted with n‐hexane to remove impurity ,then the filtrate and residue were extracted with methanol ,and the concentrated solutions were extrac‐ted with ethyl acetate and n‐butyl alcohol ,respectively .The compounds were isolated and obtained by column chromatography in‐cluding silica gel and MDS‐5 . Their structures were elucidated by means of physiochemical properties and spectral analysis . Results 5 compounds were isolated from Pueraria miri f ica .And their structures were elucidated as ：mirificoumestan（1） ,hepta‐decanoic acid（2） ,deoxymiroestrol （3） ,puerarin （4） ,and daidzin（5） ,respectively .Conclusion Compound 2 was isolated from this plant for the first time .

关 键 词：葛属 泰国葛根 化学成分 

分 类 号：R284[医药卫生—中药学]