溴己新治疗慢性支气管炎的疗效评价  

Curative effect evaluation of bromhexine for the treatment of chronic bronchitis

作　　者：邓梓辛[1] 张美祥[1] 谭璐[1] 汪曲[1] 王树平[1] 

机构地区：[1]黄冈市中心医院,438000

出　　处：《西北药学杂志》2015年第6期728-732,共5页Northwest Pharmaceutical Journal

摘　　要：目的评价溴己新治疗慢性支气管炎的疗效及安全性。方法通过检索PubMed、Cochrane library、中国期刊全文数据库(China National Knowledge Internet,CNKI)、维普数据库(Weip Database,VIP)和万方数字化期刊全文数据库;纳入随机对照试验(Randomized Controlled Trial,RCT)8篇,包括溴己新对比氨溴索、二陈汤、咳喘宁口服液、S-羧甲半胱氨酸和安慰剂组;利用Jadad质量评分工具进行方法质量评价。结果溴己新组对比氨溴索组共4个RCT,临床总有效率比较:RR=0.83,95%CI(0.76,0.91),P<0.000 1,差异有统计学意义。其余组由于文献数量少限制而进行描述性分析。结论溴己新可以有效地治疗慢性支气管炎,但是质量评分以及Meta分析显示其疗效低于氨溴索。Objective To assess the effect and safety of bromhexine for chronic bronchitis .Methods We retrieve the database inclu‐ding PubMed ,the Cochrane library ,China National Knowledge Internet （CNKI） ,Weip Database （VIP） and Wanfang Data . Eight randomized controlled trials （RCT ） comparing bromhexine with ambroxol ,Erchentang ,Kechuanning oral liquid ,S‐carboxy‐methylcysteine and placebo were included in this research .The course of treatment was more than 5 days .The Jadad quality tools was used for the quality evaluation of each study .Results There were 4 RCTs which compared bromhexine with ambroxol ,with significant difference in clinical overall efficacy [RR=0 .83 ,95% CI（0 .76 ,0 .91） ,P〈0 .000 1] .The rest groups required descrip‐tive analysis for study quantity .Conclusion Chronic bronchitis can be treated effectively by bromhexine .However ,compared with ambroxol ,the result of quality grade and Meta‐analysis reveals lower curative effect .

关 键 词：溴己新 氨溴索 慢性支气管炎 M eta分析 

分 类 号：R974[医药卫生—药品]