维生素D对老年2型糖尿病患者心血管疾病的影响  

Effects of Vitamin D on Cardiovascular Disease of Elderly Patients with Type 2 Diabetes Mellitus

作　　者：魏丽娜[1,2] 隋忠国[2] 韩冰[2] 李娅娟[2] 程成[2] 韩志武[2] 王颜刚[3] 

机构地区：[1]青岛大学药学院药理学系,山东青岛266021 [2]青岛大学附属医院药学部,山东青岛266003 [3]青岛大学附属医院内分泌科,山东青岛266003

出　　处：《中国药房》2015年第32期4570-4572,共3页China Pharmacy

摘　　要：目的:探讨维生素D与老年2型糖尿病心血管疾病发病率及危险因素间的关系。方法:回顾性收集60岁以上2型糖尿病患者94例,根据合并疾病状况分为糖尿病组(41例)和糖尿病合并心血管疾病组(53例)。检测两组患者血清25-羟维生素D[25(OH)D]水平、实验室指标等。应用多元Logistic回归分析心血管病变与危险因素的关系,应用Pearson分析25(OH)D与各危险因素的相关性。结果:糖尿病合并心血管疾病组患者25(OH)D水平、总胆固醇(TC)、血尿酸(UA)、血钙(Ca)水平与糖尿病组比较,差异有统计学意义(P<0.05);Pearson分析显示患者25(OH)D水平与年龄、纤维蛋白原(FIB)、TC、UA呈负相关,与D-二聚体、高密度脂蛋白(HDL-C)呈正相关,其中与FIB、TC呈显著相关,差异有统计学意义(P<0.01);多元Logistic回归分析显示25(OH)D缺乏是2型糖尿病心血管疾病的发病因素。结论:患者血清25(OH)D水平与年龄、FIB、TC、UA、D-二聚体、HDL-C等心血管危险因素具有相关性,维生素D缺乏是老年2型糖尿病患者心血管疾病发病的独立危险因素。OBJECTIVE： To observe the correlation of vitamin D with the incidence of cardiovascular disease and risk factors in elderly patients with type 2 diabetes mellitus. METHODS： 94 patients, aged 60 years old above, with type 2 diabetes mellitus were collected retrospectively. Those patients were divided into diabetes group （41 cases） and diabetes complicated with cardiovas- cular disease group （53 cases） according to the condition of disease. 25 （OH） D levels and lab indicators of 2 groups were detect- ed. The relationship of cardiovascular lesion with risk factor was analyzed by Multivariate Logistic regression; the correlation be- tween 25（OH）D and risk factors was analyzed by pearson analysis. RESULTS： There was statistical significance in the levels of 25 （OH）D, TC, TG, UA and Ca between diabetes group and diabetes complicated with cardiovascular disease group, with statistical significance （P〈0.05）. pearson analysis showed that the level of 25（OH）D was negatively related to age, FIB, TC and UA, and positively related to D-dimer and HDL-C, especially correlated with FIB and TC significantly, with statistical significance （P〈 0.01）. Multivariate Logistic regression analysis showed that the deficiency of 25 （OH） D was pathogenic factors of type 2 diabetes mellitus. CONCLUSIONS： There is a correlation between the level of 25（OH）D and cardiovascular risk factors as age, FIB, TC, UA, D-dimer, HDL-C. Vitamin D deficiency is the independent risk factors for cardiovascular disease in elderly patients with type 2 diabetes mellitus.

关 键 词：维生素D 2型糖尿病 心血管疾病 危险因素 

分 类 号：R969[医药卫生—药理学]