术后谵妄发病机制的研究进展  

Research of the mechanism of postoperative delirium

作　　者：王丹[1] 王颖林[1] 田国刚[1] 

机构地区：[1]中南大学湘雅医学院附属海口医院,海口市人民医院麻醉科,570100

出　　处：《国际麻醉学与复苏杂志》2015年第11期1002-1005,共4页International Journal of Anesthesiology and Resuscitation

基　　金：海南省自然科学基金（2012-SZR-04-07812167）;海南省卫生厅科研项目（2011-SWK-08-134/琼卫2011-63）

摘　　要：背景术后谵妄是一种以注意力下降和认知紊乱为特点的急性神经精神综合征，老年患者更为多见。多种因素可以造成谵妄患者认知及行为上的改变，但至今对术后谵妄的发病机制和病理生理学了解甚少。目的探讨术后谵妄的发病机制。内容就炎症因子、神经内分泌、神经递质、生物节律、高龄等几个假说论述术后谵妄可能的发病机制。趋向随着对术后谵妄发病机制的深入研究，越来越多的病理机制将被阐明，为临床提供有效的预防及治疗措施。Background Postoperative delirium refers to an acute neuropsychiatric syndrome characterized by inattention and cognitive dysfunction. The elderly seem to experience a greater chance. Multifactor cause the complex cognitive and behavioral changes observed in delirium. To date, pathogenesis and pathophysiology of delirium remain elusive. Objective This review focus on the mechanism of postoperative delirium. Content This article includes hypotheses of inflammatory cytokines, neuroendocrine, neurotransmitter, biological rhythm, aging and so on to calrify the pathogenesis of delirium. Trend With the intensive study of postoperative delirium, more and more mechanisms and pathologic processes will be found to provide new theories for effective prophylaxis and treatment of delirium in clinical.

关 键 词：术后谵妄 炎症因子 神经内分泌 神经递质 生物节律 

分 类 号：R614[医药卫生—麻醉学]