重症监护病房获得性肌无力的研究进展  

Progress in the intensive care unit-acquired weakness

作　　者：于雄伟 薄禄龙[1] 邓小明[1] 

机构地区：[1]第二军医大学附属长海医院麻醉科,上海200433 [2]中国人民解放军第二八五医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2015年第11期1033-1036,1040,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（81471845、81201492）;上海青年医师培养资助计划（20141093）

摘　　要：背景重症监护病房获得性肌无力（intensivecareunit-acquiredweakness，ICU-AW）是危重病患者常见多发的并发症。肌无力延长患者机械通气时间和住院时间，可长期影响患者生活质量。目的探究ICU-AW的发病机制及诊疗新进展。内容脓毒症和机械通气诱发ICU-AW的病理生理机制，ICU-AW的诊断、预防和治疗新进展。趋向早期控制脓毒症，缩短机械通气时间有助于ICU-AW的预防和治疗，合理选择药物、早期下床活动和电刺激疗法有助于ICU-AW肌力的恢复。Background Intensive care unit-acquired weakness （ICU-AW） has constituted a frequent, severe, and persistent complication among critically ill patients admitted to intensive care unit （ICU）. ICU-AW is responsible for prolonged mechanical ventilation and ICU stay, and it may affect the long-term quality of life after discharge. Objective To investigate the pathophysiology, diagnosis and therapy of ICU-AW. Content Pathophysiology of sepsis and mechanical ventilation （MV） induced ICU-AW, and new concepts of diagnosis, prevention and management for ICU-AW will be reviewed. Trend Various aspects contribute to the management of ICU-AW, including early treatment of sepsis, shortening the duration of MV, appropriate drug treatment , early mobilization, and electrical muscle stimulation therapy.

关 键 词：重症监护病房获得性肌无力 脓毒症 机械通气 膈肌萎缩 早期活动 肌肉电刺激 

分 类 号：R614[医药卫生—麻醉学]